Although the significance of the corneoum lines is not fully known, their analysis with the silicon replica method can be of use for toxicological purposes, if it is assumed that a substance with a toxin action creates a perturbation in the corneoum design and that such a perturbation is proportional to the toxicity of the substance. In fact, the corneoum design ought to be considered a result of the epidermic growth, which indicates the dermis vitality. Whenever a substance through the corneoum arrives to trouble the epidermic/dermic biology, a more or less visible change of the corneoum design is inevitable. In this case, the change is detected through a technique which can be use in vivo and is not at all invasive.
|Translated title of the contribution||Evaluation of the change of skin surface with the silicon replica method|
|Number of pages||4|
|Journal||Specializzati Oggi - Dermatologia|
|Publication status||Published - 1993|
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