Evaluation of the clinical performances of a large NaI(Tl) crystal 3D PET scanner

M. Picchio, A. Savi, M. Lecchi, C. Landoni, L. Gianolli, M. Brioschi, C. Rossetti, M. C. Gilardi, F. Fazio

Research output: Contribution to journalArticlepeer-review


Aim. This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scanner, C-PET (-ADAC-UGM), using a multi-ring 2D BGO PET scanner (multi-ring PET), as a reference. Methods. Thirty-seven oncological patients were studied in sequence with multi-ring PET and C-PET, within 30 days of a CT study. In order to assess the behaviour of C-PET in relation to acquisition count rate, patients were divided into 3 groups according to the count rate at the time of the C-PET scan acquisition. Group A (n=21): 3000-5000 kcounts/sec (recommended count rate range); Group B (n=8): 5000 Kcounts/sec. Results. The number of lesions detected by multi-ring PET and C-PET, classified according to size, was compared. For Group A and Group B there was a good agreement between C-PET and multi-ring PET in terms of lesion detectability (relative sensitivity: 99.9% and 96.0%, respectively), while for Group C the relative sensitivity of C-PET was 61.9%. Conclusion. Optimal performances of the C-PET scanner can thus be obtained at a count rate within or below the recommended range. Despite a lower lesion/background contrast resulting from a high scatter and random noise, the sensitivity of C-PET in detecting hypermetabolic lesions is comparable to that of multi-ring PET. These findings are discussed in relation to the physical performance of the two scanners and particularly in relation to the 3D vs 2D acquisition modality.

Original languageEnglish
Pages (from-to)90-100
Number of pages11
JournalQuarterly Journal of Nuclear Medicine
Issue number2
Publication statusPublished - Jun 2003


  • [ F]Fluorodeoxyglucose
  • Scanner performance
  • Tomography, emission computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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