Evaluation of the components of the insulin-like growth factors system in GH-deficient adults: Effects of twelve-month rhGH treatment

E. Ferrante, C. Giavoli, S. Porretti, E. Vassallo, C. L. Ronchi, A. G. Lania, P. Beck-Peccoz, Anna Spada

Research output: Contribution to journalArticlepeer-review

Abstract

The impact of GH deficiency and rhGH replacement therapy on IGF-I, IGFBP-3 and ALS levels has been widely studied. There is less information available on IGF-II levels, the component of the ternary complex poorly dependent on GH. We investigate the components of IGFs system in 36 GHD adults (28M, 8F, age 45 ± 14 yrs) before and after 12 months of rhGH therapy (mean dose 0.3 ± 0.1 mg/day). One-hundred healthy sex- and age-matched subjects were studied for comparison. At baseline, GHD patients showed IGF-I and IGF-II levels and IGFs to IGFBP-3 molar ratios that were lower than controls. During therapy, IGF-I levels increased (p <0.01) to normal range. IGF-II levels, though higher than at baseline (p <0.01), remained lower than in controls (p <0.01). ALS and IGFBP-3 significantly increased (p <0.001). These modifications resulted in normalization in IGF-I to IGFBP-3 ratio, while no change in IGF-II to IGFBP-3 ratio was observed. In conclusion, the increase of serum IGF-II levels during rhGH treatment in GHD patients probably reflects the increase in the other components of ternary complex (ALS and IGFBP-3). However, serum IGF-II levels as well as IGF-II to IGFBP-3 ratio, although increased, were definitely lower than in controls. This last result, given the increasing evidences of a direct implication of IGF-II in cancer, may further confirm the safety of rhGH replacement in adults with severe GHD as diagnosed by appropriate stimulation tests.

Original languageEnglish
Pages (from-to)352-355
Number of pages4
JournalHormone and Metabolic Research
Volume38
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • GH deficiency
  • GH therapy
  • IGFBPs
  • IGFs

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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