Evaluation of the contact-sensitizing and irritation potential of fenticonazole vaginal ovules

C. Bertulessi, P. Pigatto, A. Bigardi, P. Bosco, M. J. Lechuga, E. Colli, M. Scatigna

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Abstract

An open clinical trial was performed on 24 healthy volunteers in order to evaluate the irritation potential of fenticonazole gynecologic ovules (200 and 600 mg). The contact-sensitizing potential of the two fenticonazole preparations was also investigated. There was no evidence of irritation after treatment with fenticonazole 200-mg or 600-mg ovules. The contact-sensitizing test was performed with fenticonazole 200-mg and 600-mg ovules and their respective excipients. Two subjects (one in the fenticonazole 200-mg group and one in the fenticonazole 600-mg excipients) showed signs of mild sensitization.

Original languageEnglish
Pages (from-to)1004-1008
Number of pages5
JournalCurrent Therapeutic Research
Volume47
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

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    Bertulessi, C., Pigatto, P., Bigardi, A., Bosco, P., Lechuga, M. J., Colli, E., & Scatigna, M. (1990). Evaluation of the contact-sensitizing and irritation potential of fenticonazole vaginal ovules. Current Therapeutic Research, 47(6), 1004-1008.