Evaluation of the correlation between cardiac and sympathetic baroreflex sensitivity before orthostatic syncope

Andrea Marchi, Vlasta Bari, Beatrice De Maria, Sergio Cerutti, Karsten Heusser, Jens Tank, Jens Jordan, Franca Barbic, Raffaello Furlan, Alberto Porta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The study investigates the two different aspects of the baroreflex control resulting in two baroreflex sensitivity (BRS) indexes: i) sympathetic BRS (sBRS); ii) cardiac BRS (cBRS). sBRS was assessed as the slope of the regression line of the conditional probability of detecting a burst on the integrated muscle nerve sympathetic activity (MSNA) given an assigned diastolic arterial pressure (DAP) on DAP. cBRS was estimated from spontaneous heart period (HP) and systolic arterial pressure (SAP) via a spectral approach in the low (0.04-0-15 Hz) and high (0.15-0.5 Hz) frequency bands respectively. Both sBRS and cBRS were assessed in eight healthy subjects undergoing three experimental sessions: supine resting position (REST), 80 degrees head-up tilt test (TILT) and before the occurrence of pre-syncope symptoms (TILT-PRE). Results showed a decrease of both sBRS and cBRS during TILT and a baroreflex impairment during TILT-PRE. sBRS and cBRS were linearly correlated during TILT but became uncorrelated during TILT-PRE. Findings suggest a failure of both 'baroreflexes' and their disassociation during TILT-PRE.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2063-2066
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Marchi, A., Bari, V., De Maria, B., Cerutti, S., Heusser, K., Tank, J., Jordan, J., Barbic, F., Furlan, R., & Porta, A. (2015). Evaluation of the correlation between cardiac and sympathetic baroreflex sensitivity before orthostatic syncope. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 2063-2066). [7318793] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7318793