Valutazione dello spettro di distribuzione delle CFU-GM midollari e suo significato prognostico nelle sindromi dismielopoietiche.

Translated title of the contribution: Evaluation of the distribution spectrum of bone marrow granulocyte-CFU and its prognostic significance in dysmyelopoietic syndromes

A. Ghizzi, C. Carlo Stella, M. T. Bossi, M. Gorini

Research output: Contribution to journalArticle

Abstract

We have studied bone marrow CFU-GM growth behaviour in 13 patients with Dysmyelopoietic Syndrome by means of the analytical scoring at two sequential times of aggregates. In this way we have distinguished aggregates according to their size, in clusters or colonies and grouped them according to their "in vitro" appearance time, transformation from cluster to colony, "in vitro" survival time and "in vitro" degeneration time. This statement of the study allow us to map CFU-GM subtypes in a percentage distribution related to the total growth of CFU-GM. Comparisons between absolute number of growth of different CFU-GM subtypes in DS vs Normal subjects show both significant and not significant differences, while comparisons between percentages of growth in DS vs Normal subjects did not show significant differences. With this work we suggest an outline for the study and the interpretation of CFU-GM growth patterns in the haematological disorders at risk of evolution in acute nonlymphocytic leukemia.

Translated title of the contributionEvaluation of the distribution spectrum of bone marrow granulocyte-CFU and its prognostic significance in dysmyelopoietic syndromes
Original languageItalian
Pages (from-to)397-403
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume60
Issue number2
Publication statusPublished - Feb 28 1984

ASJC Scopus subject areas

  • Medicine(all)

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