Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals

Paola Rizza; Imerio Capone; Francesca Urbani; Enrica Montefiore; Maria Rapicetta; Paola Chionne; Angela Candido; Maria Elena Tosti; Maria Grimaldi; Ernesto Palazzini; Giuseppe Viscomi; Carmela Cursaro; Marzia Margotti; Alessandra Scuteri; Pietro Andreone; Elisabeth Taylor; Elisabeth A. Haygreen; David F. Tough; Persephone Borrow; Marina Selleri; Concetta Castilletti; Maria Capobianchi; Filippo Belardelli

doi:10.1016/j.vaccine.2007.12.044

Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals

Paola Rizza, Imerio Capone, Francesca Urbani, Enrica Montefiore, Maria Rapicetta, Paola Chionne, Angela Candido, Maria Elena Tosti, Maria Grimaldi, Ernesto Palazzini, Giuseppe Viscomi, Carmela Cursaro, Marzia Margotti, Alessandra Scuteri, Pietro Andreone, Elisabeth Taylor, Elisabeth A. Haygreen, David F. Tough, Persephone Borrow, Marina SelleriConcetta Castilletti, Maria Capobianchi, Filippo Belardelli

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-α administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals. No significant enhancing effect on the antibody response was observed, in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells, which may be suggestive of an IFN-mediated activation of antigen presenting cells. We conclude that, under the conditions used in this trial, natural IFN-α does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals.

Original language	English
Pages (from-to)	1038-1049
Number of pages	12
Journal	Vaccine
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2007.12.044
Publication status	Published - Feb 20 2008

Keywords

Adjuvant
Interferon
Vaccine

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)

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10.1016/j.vaccine.2007.12.044

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Rizza, P., Capone, I., Urbani, F., Montefiore, E., Rapicetta, M., Chionne, P., Candido, A., Tosti, M. E., Grimaldi, M., Palazzini, E., Viscomi, G., Cursaro, C., Margotti, M., Scuteri, A., Andreone, P., Taylor, E., Haygreen, E. A., Tough, D. F., Borrow, P., ... Belardelli, F. (2008). Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals. Vaccine, 26(8), 1038-1049. https://doi.org/10.1016/j.vaccine.2007.12.044

Rizza, P, Capone, I, Urbani, F, Montefiore, E, Rapicetta, M, Chionne, P, Candido, A, Tosti, ME, Grimaldi, M, Palazzini, E, Viscomi, G, Cursaro, C, Margotti, M, Scuteri, A, Andreone, P, Taylor, E, Haygreen, EA, Tough, DF, Borrow, P, Selleri, M, Castilletti, C, Capobianchi, M & Belardelli, F 2008, 'Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals', Vaccine, vol. 26, no. 8, pp. 1038-1049. https://doi.org/10.1016/j.vaccine.2007.12.044

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AU - Rapicetta, Maria

AU - Chionne, Paola

AU - Candido, Angela

AU - Tosti, Maria Elena

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AU - Viscomi, Giuseppe

AU - Cursaro, Carmela

AU - Margotti, Marzia

AU - Scuteri, Alessandra

AU - Andreone, Pietro

AU - Taylor, Elisabeth

AU - Haygreen, Elisabeth A.

AU - Tough, David F.

AU - Borrow, Persephone

AU - Selleri, Marina

AU - Castilletti, Concetta

AU - Capobianchi, Maria

AU - Belardelli, Filippo

PY - 2008/2/20

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N2 - HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-α administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals. No significant enhancing effect on the antibody response was observed, in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells, which may be suggestive of an IFN-mediated activation of antigen presenting cells. We conclude that, under the conditions used in this trial, natural IFN-α does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals.

AB - HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-α administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals. No significant enhancing effect on the antibody response was observed, in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells, which may be suggestive of an IFN-mediated activation of antigen presenting cells. We conclude that, under the conditions used in this trial, natural IFN-α does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals.

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Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals

Abstract

Keywords

ASJC Scopus subject areas

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