Evaluation of the effects of human leukocyte IFN-α on the immune response to the HBV vaccine in healthy unvaccinated individuals

Paola Rizza, Imerio Capone, Francesca Urbani, Enrica Montefiore, Maria Rapicetta, Paola Chionne, Angela Candido, Maria Elena Tosti, Maria Grimaldi, Ernesto Palazzini, Giuseppe Viscomi, Carmela Cursaro, Marzia Margotti, Alessandra Scuteri, Pietro Andreone, Elisabeth Taylor, Elisabeth A. Haygreen, David F. Tough, Persephone Borrow, Marina SelleriConcetta Castilletti, Maria Capobianchi, Filippo Belardelli

Research output: Contribution to journalArticlepeer-review

Abstract

HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-α administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals. No significant enhancing effect on the antibody response was observed, in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells, which may be suggestive of an IFN-mediated activation of antigen presenting cells. We conclude that, under the conditions used in this trial, natural IFN-α does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals.

Original languageEnglish
Pages (from-to)1038-1049
Number of pages12
JournalVaccine
Volume26
Issue number8
DOIs
Publication statusPublished - Feb 20 2008

Keywords

  • Adjuvant
  • Interferon
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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