Evaluation of the Efficacy and Tolerability of a New Topical Formulation of Flurbiprofen in Acute Soft Tissue Injuries

A. Memeo, F. Garofoli, G. Peretti

Research output: Contribution to journalArticlepeer-review

Abstract

100 patients with acute trauma to the muscle-tendon entered this randomised double-blind study to evaluate the efficacy and tolerability of a new topical transcutaneous preparation containing 40mg flurbiprofen versus a matching placebo. Patches were applied twice daily for 7 days. A general improvement from baseline was reported with both treatments, but there was a significant improvement in pain on movement in favour of the flurbiprofen transcutaneous patch. Moreover, the flurbiprofen patch was judged to be more effective than or as effective as the oral formulation in 72% of the cases. Patients tolerated the patch well and it was well accepted by both patients and physicians. The results suggest, therefore, that the flurbiprofen transcutaneous patch can aid pain relief and quicken the functional recovery from soft tissue injuries.

Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalDrug Investigation
Volume4
Issue number5
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology (medical)

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