Abstract
The aim of this open-label prospective study is to evaluate the effectiveness of zonisamide (ZNS) in paients with refractory partial epilepsy. The study is divided into three periods: a) baseline (3 months at stable therapy); b) ZNS titration up to 50 mg b.i.d. (> 2 months); c) follow-up period with ZNS dose increases in relation to clinical judgement. 45 pts were enrolled (mean age 40 years, 32/45 with Remote Symptomatic Partial Epilepsy). 33 pts, with at least three months of follow-up, entered efficacy analysis: it has been observed a statistically significant reduction in seizure monthly frequency during last three months compared to baseline (mean+SD 22.6 + 46.1 vs 12.5+22.4, respectively) (p = 0.004). 17 patients complained adverse events, which caused drop-out in 9 cases.
Translated title of the contribution | Evaluation of the efficacy and tolerability of zonisamide as adjunctive therapy in patients with refractory partial epilepsy |
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Original language | Italian |
Pages (from-to) | 200-201 |
Number of pages | 2 |
Journal | Bollettino - Lega Italiana contro l'Epilessia |
Issue number | 140 |
Publication status | Published - Apr 2010 |
ASJC Scopus subject areas
- Clinical Neurology