Valutazione dell'efficacia e della tollerabilità della zonisamide come terapia aggiuntiva in pazienti con epilessia focale farmacoresistente

Translated title of the contribution: Evaluation of the efficacy and tolerability of zonisamide as adjunctive therapy in patients with refractory partial epilepsy

V. Durante, G. Boero, T. Francavilla, N. Pietrafusa, F. Maulucci, M. Ladogana, P. Lamberti, M. Trivisano, A. La Neve

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this open-label prospective study is to evaluate the effectiveness of zonisamide (ZNS) in paients with refractory partial epilepsy. The study is divided into three periods: a) baseline (3 months at stable therapy); b) ZNS titration up to 50 mg b.i.d. (> 2 months); c) follow-up period with ZNS dose increases in relation to clinical judgement. 45 pts were enrolled (mean age 40 years, 32/45 with Remote Symptomatic Partial Epilepsy). 33 pts, with at least three months of follow-up, entered efficacy analysis: it has been observed a statistically significant reduction in seizure monthly frequency during last three months compared to baseline (mean+SD 22.6 + 46.1 vs 12.5+22.4, respectively) (p = 0.004). 17 patients complained adverse events, which caused drop-out in 9 cases.

Translated title of the contributionEvaluation of the efficacy and tolerability of zonisamide as adjunctive therapy in patients with refractory partial epilepsy
Original languageItalian
Pages (from-to)200-201
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number140
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology

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