Evaluation of the efficacy of slow-release nifedipine in systemic hypertension by ambulatory intraarterial blood pressure monitoring

Domenico Bonaduce, Vincenzo Canonico, Felice Mazza, Antonio Nicolino, Nicola Ferrara, Massimo Chiariello, Mario Condorelli

Research output: Contribution to journalArticle

Abstract

We assessed the effect on blood pressure of administration of slow-release nifedipine tablets (20 mg) by continuous intraarterial blood pressure monitoring (Oxford system) in 10 patients with untreated essential hypertension. Blood pressure was recorded under control conditions and during nifedipine therapy. During each monitoring period patients were instructed to perform various types of exercise. The initial dose of nifedipine was 20 mg twice a day (8:00 a.m. and 8:00 p.m.). For patients in whom arterial pressure control was not achieved, the dose of the drug was increased at weekly intervals, first to 40 mg in the morning and 20 mg at night and then to 40 mg twice a day. The average daily dose was 52 mg. Nifedipine twice a day significantly reduced systolic and diastolic blood pressures both during the day and during the night. The rise in blood pressure due to dynamic or isometric exercise or to mental testing was blunted. Heart rate did not change. Orthostatic hypotension was not observed, and there were only minor side effects, which did not require withdrawal of the patient from the trial. Unavailability of nifedipine from this preparation svas satisfactory, as shown by plasma concentrations which remained constantly in the therapeutic range. Thus, slow-release nifedipine given twice a day represents an effective treatment in patients with essential arterial hypertension. The reduced frequency of administration required may improve patient compliance with this treatment.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume7
Issue number1
Publication statusPublished - 1985

Keywords

  • Continuous blood pressure recording
  • Hypertension
  • Slow-release nifedipine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Evaluation of the efficacy of slow-release nifedipine in systemic hypertension by ambulatory intraarterial blood pressure monitoring'. Together they form a unique fingerprint.

  • Cite this

    Bonaduce, D., Canonico, V., Mazza, F., Nicolino, A., Ferrara, N., Chiariello, M., & Condorelli, M. (1985). Evaluation of the efficacy of slow-release nifedipine in systemic hypertension by ambulatory intraarterial blood pressure monitoring. Journal of Cardiovascular Pharmacology, 7(1), 145-151.