Evaluation of the host defense system in asthmatic patients

Giuliana Gialdroni Grassi, Pietro Zanon, Anna Fietta, Virginia De Rose, Patrizia Mangiarotti, Carlo Grassi

Research output: Contribution to journalArticlepeer-review

Abstract

The efficiency of some components of the host defense system has been evaluated in 32 atopic patients with rhinitis, asthma or asthma and rhinitis. No alterations in components of complement (C3 and C4), serum immunoglobulins (IgG, IgA, and IgM) and neutrophil functional parameters were found. As expected, serum IgE values were higher than in controls. A decreased percentage of total circulating T lymphocytes, an increased percentage of Ia1-positive cells, but normal values of OKT4- and OKT8-positive T lymphocytes were demonstrated. However, a greater heterogeneity in the distribution of the suppressor-cytotoxic subset was shown in atopic patients.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalRespiration
Volume50
DOIs
Publication statusPublished - 1986

Keywords

  • Host defense system
  • Polymorphonuclear neutrophil function tests
  • T-lymphocyte subsets

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

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