Evaluation of the host defense system in asthmatic patients

Giuliana Gialdroni Grassi; Pietro Zanon; Anna Fietta; Virginia De Rose; Patrizia Mangiarotti; Carlo Grassi

doi:10.1159/000195105

Evaluation of the host defense system in asthmatic patients

Giuliana Gialdroni Grassi, Pietro Zanon, Anna Fietta, Virginia De Rose, Patrizia Mangiarotti, Carlo Grassi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The efficiency of some components of the host defense system has been evaluated in 32 atopic patients with rhinitis, asthma or asthma and rhinitis. No alterations in components of complement (C3 and C4), serum immunoglobulins (IgG, IgA, and IgM) and neutrophil functional parameters were found. As expected, serum IgE values were higher than in controls. A decreased percentage of total circulating T lymphocytes, an increased percentage of Ia1-positive cells, but normal values of OKT4- and OKT8-positive T lymphocytes were demonstrated. However, a greater heterogeneity in the distribution of the suppressor-cytotoxic subset was shown in atopic patients.

Original language	English
Pages (from-to)	83-91
Number of pages	9
Journal	Respiration
Volume	50
DOIs	https://doi.org/10.1159/000195105
Publication status	Published - 1986

Keywords

Host defense system
Polymorphonuclear neutrophil function tests
T-lymphocyte subsets

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Physiology

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10.1159/000195105

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title = "Evaluation of the host defense system in asthmatic patients",

abstract = "The efficiency of some components of the host defense system has been evaluated in 32 atopic patients with rhinitis, asthma or asthma and rhinitis. No alterations in components of complement (C3 and C4), serum immunoglobulins (IgG, IgA, and IgM) and neutrophil functional parameters were found. As expected, serum IgE values were higher than in controls. A decreased percentage of total circulating T lymphocytes, an increased percentage of Ia1-positive cells, but normal values of OKT4- and OKT8-positive T lymphocytes were demonstrated. However, a greater heterogeneity in the distribution of the suppressor-cytotoxic subset was shown in atopic patients.",

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AU - Mangiarotti, Patrizia

AU - Grassi, Carlo

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