Evaluation of the Impact of a New Synthetic Vitamin E-Bonded Membrane on the Hypo-Responsiveness to the Erythropoietin Therapy in Hemodialysis Patients: A Multicenter Study

Francesco Locatelli, Simeone Andrulli, Sara Maria Viganò, Massimo Concetti, Sauro Urbini, Franca Giacchino, Roberto Broccoli, Filippo Aucella, Maria Cossu, Paolo Conti, Laura Fattori, Giorgio Punzo, Daniela Angelini, Marco Peruzzini, Salvatore DI Giulio, Marta Piroddi, Francesco Galli, Lucia Del Vecchio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Oxidative stress has been related to hypo-response to erythropoiesis-stimulating agents (ESAs) in hemodialysis (HD) patients. The aim of this study was to verify whether vitamin E (ViE) on a synthetic polysulfone dialyzer can improve ESA responsiveness. Methods: This controlled, multicenter study involved 93 HD patients on stable ESA therapy, who were randomized to either ViE-coated polysulfone dialyzer or to a low-flux synthetic dialyzer. The primary outcome measure was the change in ESA resistance index (ERI) from baseline. Results: Mean ERI decreased in the ViE group by 1.45 IU/kg∗g/dl and increased in the control group by 0.53 IU/kg∗g/dl, with a mean difference of 1.98 IU/kg∗g/dl (p = 0.001 after adjusting for baseline ERI, as foreseen by the study protocol). Baseline ERI was inversely related to its changes during follow-up only in the control group (R2 = 0.29). Conclusions: The ViE dialyzer can improve ESA response in HD patients. Changes in ERI during follow-up are independent from baseline ERI only in the ViE group. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=453442.

Original languageEnglish
Pages (from-to)338-345
Number of pages8
JournalBlood Purification
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 1 2017
Externally publishedYes

Keywords

  • Erythropoiesis-stimulating agent resistance
  • Erythropoiesis-stimulating agent responsiveness
  • Erythropoietin
  • Hemodialysis
  • Vitamin E

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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