TY - JOUR
T1 - Evaluation of the minimum iodine concentration for contrast enhanced subtraction mammography
AU - Baldelli, P.
AU - Bravin, A.
AU - Di Maggio, C.
AU - Gennaro, G.
AU - Gambaccini, M.
AU - Sarnelli, A.
AU - Taibi, A.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - The aim of this work is to investigate the use of iodine based contrast media in mammography with two different double exposure techniques: K-Edge Subtraction Mammography and Temporal Subtraction Mammography. Both techniques have been investigated by using monochromatic beams produced at a synchrotron radiation facility and conventional beams obtained with a clinical digital mammography system. A dedicated three-component phantom containing cavities filled with different iodine concentrations has been developed and used for measurements. For each technique, information about the minimum iodine concentration which provides a significant enhancement of the detectability of the pathology by minimizing the risk due to high dose and high concentration of contrast medium has been obtained. In particular for cavities of 5 and 8 mm of diameter filled with iodine solutions (0, 2, 4, 8, 16, 32 mg / ml), the minimum concentrations needed to obtain a contrast-to-noise ratio of 5 with a mean glandular dose of 2 mGy have been obtained.
AB - The aim of this work is to investigate the use of iodine based contrast media in mammography with two different double exposure techniques: K-Edge Subtraction Mammography and Temporal Subtraction Mammography. Both techniques have been investigated by using monochromatic beams produced at a synchrotron radiation facility and conventional beams obtained with a clinical digital mammography system. A dedicated three-component phantom containing cavities filled with different iodine concentrations has been developed and used for measurements. For each technique, information about the minimum iodine concentration which provides a significant enhancement of the detectability of the pathology by minimizing the risk due to high dose and high concentration of contrast medium has been obtained. In particular for cavities of 5 and 8 mm of diameter filled with iodine solutions (0, 2, 4, 8, 16, 32 mg / ml), the minimum concentrations needed to obtain a contrast-to-noise ratio of 5 with a mean glandular dose of 2 mGy have been obtained.
KW - Contrast medium
KW - Dual-energy
KW - Mammography
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U2 - 10.1016/j.nima.2007.06.109
DO - 10.1016/j.nima.2007.06.109
M3 - Article
AN - SCOPUS:34548477470
VL - 580
SP - 1115
EP - 1118
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
SN - 0168-9002
IS - 2
ER -