Evaluation of the minimum iodine concentration for contrast enhanced subtraction mammography

P. Baldelli, A. Bravin, C. Di Maggio, G. Gennaro, M. Gambaccini, A. Sarnelli, A. Taibi

Research output: Contribution to journalArticlepeer-review


The aim of this work is to investigate the use of iodine based contrast media in mammography with two different double exposure techniques: K-Edge Subtraction Mammography and Temporal Subtraction Mammography. Both techniques have been investigated by using monochromatic beams produced at a synchrotron radiation facility and conventional beams obtained with a clinical digital mammography system. A dedicated three-component phantom containing cavities filled with different iodine concentrations has been developed and used for measurements. For each technique, information about the minimum iodine concentration which provides a significant enhancement of the detectability of the pathology by minimizing the risk due to high dose and high concentration of contrast medium has been obtained. In particular for cavities of 5 and 8 mm of diameter filled with iodine solutions (0, 2, 4, 8, 16, 32 mg / ml), the minimum concentrations needed to obtain a contrast-to-noise ratio of 5 with a mean glandular dose of 2 mGy have been obtained.

Original languageEnglish
Pages (from-to)1115-1118
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Issue number2
Publication statusPublished - Oct 1 2007


  • Contrast medium
  • Dual-energy
  • Mammography

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics


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