Evaluation of the natural immunity in pups inoculated with a modified-live canine parvovirus type 2b (CPV-2b) strain

A. Pratelli, M. Altamura, D. Buonavoglia, M. Pepe, A. Tafaro, A. Lembo, F. Cirone, M. Tempesta, E. Jirillo, C. Buonavoglia

Research output: Contribution to journalArticle

Abstract

Three pups 2-4 months old were vaccinated subcutaneously with the modified live canine parvovirus, CPV-2b/29-97 strain. During an observation period of two weeks pups remained clinically health, exhibiting a vigorous post-vaccinal active serological response (haemoagglutinating inhibiting antibody titers for CPV-2 ranging from 1:2560 to 1:5120 at 21 days post inoculation). Phagocytosis and killing of Candida albicans exerted by polymorphonuclear cells and monocytes did not undergo significant modifications 3-6 days post vaccination up to 30 days. Antibacterial activity mediated by peripheral blood lymphocytes (Salmonella typhi was used as a target) was slightly, but not significantly decreased 3 days post vaccination. Conclusively, in pups the CPV type 2b vaccine seems to be safe as far as natural immune responses are concerned, while its immunogenicity is preserved.

Original languageEnglish
Pages (from-to)451-464
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume22
Issue number3
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Immunology
  • Pharmacology
  • Toxicology

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    Pratelli, A., Altamura, M., Buonavoglia, D., Pepe, M., Tafaro, A., Lembo, A., Cirone, F., Tempesta, M., Jirillo, E., & Buonavoglia, C. (2000). Evaluation of the natural immunity in pups inoculated with a modified-live canine parvovirus type 2b (CPV-2b) strain. Immunopharmacology and Immunotoxicology, 22(3), 451-464.