Evaluation of the nature of mildly prolonged prothrombin times

M. G. Mazzucconi, G. Mariani, A. Chistolini, R. P. Lasagni, M. Motta, A. Ghirardini, D. Altieri, P. M. Mannucci, F. Mandelli

Research output: Contribution to journalArticle

Abstract

Twenty-one asymptomatic individuals with a mildly prolonged prothrombin time (>2 SD from the prothrombin time of the reference plasma) were found to have a mild isolated factor VII (F VII) defect (x̄ 38.8 U/dl; SD 13.2). Factor VII antigen levels were also found to be reduced (x̄ 45.5 U/dl; SD 7.8) in 13 of them. These figures were compared with those of 50 normals and 28 obligatory heterozygotes for F VII deficiency. The phenotypical behaviors in the propositi were found to be equal to those of the F VII congenital deficiency heterozygotes: the discrepant one (VII+) and the nondiscrepant one (VII(-/R). Fifteen families of the propositi could also be studied, totalling 55 additional individuals; in 25 of them (ten pedigrees) a mild F VII deficiency was found showing the same phenotypical features of the corresponding propositi. We therefore believe that these individuals with mild F VII deficiency can be considered as heterozygotes for the defect, since (1) the other vitamin K-dependent clotting factors were normal; (2) the defect is transmitted throughout the kindred with the same mode of inheritance as F VII congenital deficiency; and (3) F VII:C and F VII:Ag levels are highly comparable with those of known obligatory heterozygotes for F VII deficiency. On the grounds of a careful statistical analysis we propose a formula which allows a discrimination between the two phenotypes of the heterozygotes for F VII congenital deficiency. In addition it is suggested that sensitive tissue thromboplastins should be used to pick up these mild defects.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalAmerican Journal of Hematology
Volume24
Issue number1
DOIs
Publication statusPublished - 1987

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Factor VII Deficiency
Prothrombin Time
Heterozygote
Factor VII
Vitamin K 1
Blood Coagulation Factors
Thromboplastin
Pedigree
Phenotype
Antigens

ASJC Scopus subject areas

  • Hematology

Cite this

Mazzucconi, M. G., Mariani, G., Chistolini, A., Lasagni, R. P., Motta, M., Ghirardini, A., ... Mandelli, F. (1987). Evaluation of the nature of mildly prolonged prothrombin times. American Journal of Hematology, 24(1), 37-45. https://doi.org/10.1002/ajh.2830240106

Evaluation of the nature of mildly prolonged prothrombin times. / Mazzucconi, M. G.; Mariani, G.; Chistolini, A.; Lasagni, R. P.; Motta, M.; Ghirardini, A.; Altieri, D.; Mannucci, P. M.; Mandelli, F.

In: American Journal of Hematology, Vol. 24, No. 1, 1987, p. 37-45.

Research output: Contribution to journalArticle

Mazzucconi, MG, Mariani, G, Chistolini, A, Lasagni, RP, Motta, M, Ghirardini, A, Altieri, D, Mannucci, PM & Mandelli, F 1987, 'Evaluation of the nature of mildly prolonged prothrombin times', American Journal of Hematology, vol. 24, no. 1, pp. 37-45. https://doi.org/10.1002/ajh.2830240106
Mazzucconi MG, Mariani G, Chistolini A, Lasagni RP, Motta M, Ghirardini A et al. Evaluation of the nature of mildly prolonged prothrombin times. American Journal of Hematology. 1987;24(1):37-45. https://doi.org/10.1002/ajh.2830240106
Mazzucconi, M. G. ; Mariani, G. ; Chistolini, A. ; Lasagni, R. P. ; Motta, M. ; Ghirardini, A. ; Altieri, D. ; Mannucci, P. M. ; Mandelli, F. / Evaluation of the nature of mildly prolonged prothrombin times. In: American Journal of Hematology. 1987 ; Vol. 24, No. 1. pp. 37-45.
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