Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatments

Erika Di Betta, Laura Fariselli, Achille Bergantin, Federica Locatelli, Antonella Del Vecchio, Sara Broggi, Maria Luisa Fumagalli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects. Methods: Treatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a multileaf collimator, a CyberKnife® system (before and after a supplemental shielding was applied), a TomoTherapy® system, and a Gamma Knife® unit. For each treatment, 5 Gy were prescribed to the target. Measurements were performed with thermoluminescent dosimeters inserted roughly in the position of the thyroid, sternum, upper lung, lower lung, and gonads. Results: Mean doses ranged from of 4.1 (Gamma Knife) to 62.8 mGy (LINAC with cones) in the thyroid, from 2.3 (TomoTherapy) to 30 mGy (preshielding CyberKnife) in the sternum, from 1.7 (TomoTherapy) to 20 mGy (preshielding CyberKnife) in the upper part of the lungs, from 0.98 (Gamma Knife) to 15 mGy (preshielding CyberKnife) in the lower part of the lungs, and between 0.3 (Gamma Knife) and 10 mGy (preshielding CyberKnife) in the gonads. Conclusions: The peripheral dose absorbed in the sites of interest with a 5 Gy fraction is low. Although the risk of adverse side effects calculated for 20 Gy delivered in 5 Gy fractions is negligible, in the interest of optimum patient radioprotection, further studies are needed to determine the weight of each contributor to the peripheral dose.

Original languageEnglish
Pages (from-to)3587-3594
Number of pages8
JournalMedical Physics
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • CyberKnife®
  • Gamma Knife®
  • multileaf collimator
  • peripheral dose
  • stereotactic radiotherapy (SRT)

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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