Evaluation of the positive effects on insulin-resistance and β-cell measurements of vildagliptin in addition to metformin in type 2 diabetic patients

Giuseppe Derosa, Pietro D. Ragonesi, Anna Carbone, Elena Fogari, Angela D'Angelo, Arrigo F G Cicero, Pamela Maffioli

Research output: Contribution to journalArticle

Abstract

We evaluated the positive effects of vildagliptin in addition to metformin on glycemic control and β-cell function in type 2 diabetic patients. One hundred and seventy-one type 2 diabetic patients were instructed to add vildaglipin 50 mg twice a day or placebo to metformin for 12 months. Body mass index (BMI), glycemic control, fasting plasma insulin (FPI), HOMA-IR, HOMA-β, fasting plasma proinsulin (FPPr), proinsulin/fasting plasma insulin ratio (Pr/FPI ratio), C-peptide, glucagon, vaspin, visfatin, and omentin-1 were evaluated. Before, and after 12 months since the addition of vildagliptin, patients underwent a combined euglycemic hyperinsulinemic and hyperglycemic clamp, with subsequent arginine stimulation. Vildagliptin + metformin were more effective than placebo + metformin in reducing body weight and BMI, glycemic control, HOMA-IR, glucagon and insulin resistance measurements. Vildagliptin + metformin gave also a better increase of HOMA-β, and of all β-cell parameters after the clamp. We also recorded a significant correlation between M value increase and the decrease of vaspin, visfatin, and omentin-1 obtained with vildagliptin + metformin. Vildagliptin, in addition to metformin, proved to be effective in improving β-cell function and in reducing insulin resistance measurements.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalPharmacological Research
Volume73
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Insulin-resistance
  • Metformin
  • Omentin-1
  • Vaspin
  • Vildagliptin
  • Visfatin

ASJC Scopus subject areas

  • Pharmacology

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