Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Francesco Buccisano, Luca Maurillo, Anna Tamburini, Giovanni Del Poeta, Maria Ilaria Del Principe, Emanuele Ammatuna, Maria Irno Consalvo, Selenia Campagna, Licia Ottaviani, Chiara Sarlo, Daniela Renzi, Sabrina Faccia, Daniela Fraboni, Francesco Lo Coco, Sergio Amadori, Adriano Venditti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 + blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 + blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 + blast cells of 18 sAML and CD34 + stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalEuropean Journal of Haematology
Volume80
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Adhesion molecules
  • Flow-cytometry
  • Intercellular adhesion molecule 1
  • L-selectin
  • Myelodysplastic syndromes
  • Secondary acute myeloid leukaemia

ASJC Scopus subject areas

  • Hematology

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