Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Francesco Buccisano; Luca Maurillo; Anna Tamburini; Giovanni Del Poeta; Maria Ilaria Del Principe; Emanuele Ammatuna; Maria Irno Consalvo; Selenia Campagna; Licia Ottaviani; Chiara Sarlo; Daniela Renzi; Sabrina Faccia; Daniela Fraboni; Francesco Lo Coco; Sergio Amadori; Adriano Venditti

doi:10.1111/j.1600-0609.2007.00986.x

Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Francesco Buccisano, Luca Maurillo, Anna Tamburini, Giovanni Del Poeta, Maria Ilaria Del Principe, Emanuele Ammatuna, Maria Irno Consalvo, Selenia Campagna, Licia Ottaviani, Chiara Sarlo, Daniela Renzi, Sabrina Faccia, Daniela Fraboni, Francesco Lo Coco, Sergio Amadori, Adriano Venditti

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 ⁺ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 ⁺ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 ⁺ blast cells of 18 sAML and CD34 ⁺ stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio

Original language	English
Pages (from-to)	107-114
Number of pages	8
Journal	European Journal of Haematology
Volume	80
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0609.2007.00986.x
Publication status	Published - Feb 2008

Keywords

Adhesion molecules
Flow-cytometry
Intercellular adhesion molecule 1
L-selectin
Myelodysplastic syndromes
Secondary acute myeloid leukaemia

ASJC Scopus subject areas

Hematology

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Buccisano, F., Maurillo, L., Tamburini, A., Del Poeta, G., Del Principe, M. I., Ammatuna, E., Consalvo, M. I., Campagna, S., Ottaviani, L., Sarlo, C., Renzi, D., Faccia, S., Fraboni, D., Coco, F. L., Amadori, S., & Venditti, A. (2008). Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. European Journal of Haematology, 80(2), 107-114. https://doi.org/10.1111/j.1600-0609.2007.00986.x

Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. / Buccisano, Francesco; Maurillo, Luca; Tamburini, Anna; Del Poeta, Giovanni; Del Principe, Maria Ilaria; Ammatuna, Emanuele; Consalvo, Maria Irno; Campagna, Selenia; Ottaviani, Licia; Sarlo, Chiara; Renzi, Daniela; Faccia, Sabrina; Fraboni, Daniela; Coco, Francesco Lo; Amadori, Sergio; Venditti, Adriano.

In: European Journal of Haematology, Vol. 80, No. 2, 02.2008, p. 107-114.

Research output: Contribution to journal › Article › peer-review

Buccisano, F, Maurillo, L, Tamburini, A, Del Poeta, G, Del Principe, MI, Ammatuna, E, Consalvo, MI, Campagna, S, Ottaviani, L, Sarlo, C, Renzi, D, Faccia, S, Fraboni, D, Coco, FL, Amadori, S & Venditti, A 2008, 'Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes', European Journal of Haematology, vol. 80, no. 2, pp. 107-114. https://doi.org/10.1111/j.1600-0609.2007.00986.x

Buccisano, Francesco ; Maurillo, Luca ; Tamburini, Anna ; Del Poeta, Giovanni ; Del Principe, Maria Ilaria ; Ammatuna, Emanuele ; Consalvo, Maria Irno ; Campagna, Selenia ; Ottaviani, Licia ; Sarlo, Chiara ; Renzi, Daniela ; Faccia, Sabrina ; Fraboni, Daniela ; Coco, Francesco Lo ; Amadori, Sergio ; Venditti, Adriano. / Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. In: European Journal of Haematology. 2008 ; Vol. 80, No. 2. pp. 107-114.

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abstract = "Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 + blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 + blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 + blast cells of 18 sAML and CD34 + stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio ",

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AU - Del Principe, Maria Ilaria

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AU - Consalvo, Maria Irno

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AU - Ottaviani, Licia

AU - Sarlo, Chiara

AU - Renzi, Daniela

AU - Faccia, Sabrina

AU - Fraboni, Daniela

AU - Coco, Francesco Lo

AU - Amadori, Sergio

AU - Venditti, Adriano

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Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Abstract

Keywords

ASJC Scopus subject areas

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