Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Francesco Buccisano; Luca Maurillo; Anna Tamburini; Giovanni Del Poeta; Maria Ilaria Del Principe; Emanuele Ammatuna; Maria Irno Consalvo; Selenia Campagna; Licia Ottaviani; Chiara Sarlo; Daniela Renzi; Sabrina Faccia; Daniela Fraboni; Francesco Lo Coco; Sergio Amadori; Adriano Venditti

doi:10.1111/j.1600-0609.2007.00986.x

Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Francesco Buccisano, Luca Maurillo, Anna Tamburini, Giovanni Del Poeta, Maria Ilaria Del Principe, Emanuele Ammatuna, Maria Irno Consalvo, Selenia Campagna, Licia Ottaviani, Chiara Sarlo, Daniela Renzi, Sabrina Faccia, Daniela Fraboni, Francesco Lo Coco, Sergio Amadori, Adriano Venditti

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 ⁺ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 ⁺ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 ⁺ blast cells of 18 sAML and CD34 ⁺ stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio

Original language	English
Pages (from-to)	107-114
Number of pages	8
Journal	European Journal of Haematology
Volume	80
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0609.2007.00986.x
Publication status	Published - Feb 2008

Keywords

Adhesion molecules
Flow-cytometry
Intercellular adhesion molecule 1
L-selectin
Myelodysplastic syndromes
Secondary acute myeloid leukaemia

ASJC Scopus subject areas

Hematology

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10.1111/j.1600-0609.2007.00986.x

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Buccisano, F., Maurillo, L., Tamburini, A., Del Poeta, G., Del Principe, M. I., Ammatuna, E., Consalvo, M. I., Campagna, S., Ottaviani, L., Sarlo, C., Renzi, D., Faccia, S., Fraboni, D., Coco, F. L., Amadori, S., & Venditti, A. (2008). Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. European Journal of Haematology, 80(2), 107-114. https://doi.org/10.1111/j.1600-0609.2007.00986.x

Buccisano, F, Maurillo, L, Tamburini, A, Del Poeta, G, Del Principe, MI, Ammatuna, E, Consalvo, MI, Campagna, S, Ottaviani, L, Sarlo, C, Renzi, D, Faccia, S, Fraboni, D, Coco, FL, Amadori, S & Venditti, A 2008, 'Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes', European Journal of Haematology, vol. 80, no. 2, pp. 107-114. https://doi.org/10.1111/j.1600-0609.2007.00986.x

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abstract = "Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 + blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 + blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 + blast cells of 18 sAML and CD34 + stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio ",

keywords = "Adhesion molecules, Flow-cytometry, Intercellular adhesion molecule 1, L-selectin, Myelodysplastic syndromes, Secondary acute myeloid leukaemia",

author = "Francesco Buccisano and Luca Maurillo and Anna Tamburini and {Del Poeta}, Giovanni and {Del Principe}, {Maria Ilaria} and Emanuele Ammatuna and Consalvo, {Maria Irno} and Selenia Campagna and Licia Ottaviani and Chiara Sarlo and Daniela Renzi and Sabrina Faccia and Daniela Fraboni and Coco, {Francesco Lo} and Sergio Amadori and Adriano Venditti",

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doi = "10.1111/j.1600-0609.2007.00986.x",

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AU - Buccisano, Francesco

AU - Maurillo, Luca

AU - Tamburini, Anna

AU - Del Poeta, Giovanni

AU - Del Principe, Maria Ilaria

AU - Ammatuna, Emanuele

AU - Consalvo, Maria Irno

AU - Campagna, Selenia

AU - Ottaviani, Licia

AU - Sarlo, Chiara

AU - Renzi, Daniela

AU - Faccia, Sabrina

AU - Fraboni, Daniela

AU - Coco, Francesco Lo

AU - Amadori, Sergio

AU - Venditti, Adriano

PY - 2008/2

Y1 - 2008/2

N2 - Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 + blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 + blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 + blast cells of 18 sAML and CD34 + stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio

AB - Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34 + blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34 + blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34 + blast cells of 18 sAML and CD34 + stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio

KW - Adhesion molecules

KW - Flow-cytometry

KW - Intercellular adhesion molecule 1

KW - L-selectin

KW - Myelodysplastic syndromes

KW - Secondary acute myeloid leukaemia

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Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

Abstract

Keywords

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