TY - JOUR
T1 - Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes
AU - Buccisano, Francesco
AU - Maurillo, Luca
AU - Tamburini, Anna
AU - Del Poeta, Giovanni
AU - Del Principe, Maria Ilaria
AU - Ammatuna, Emanuele
AU - Consalvo, Maria Irno
AU - Campagna, Selenia
AU - Ottaviani, Licia
AU - Sarlo, Chiara
AU - Renzi, Daniela
AU - Faccia, Sabrina
AU - Fraboni, Daniela
AU - Coco, Francesco Lo
AU - Amadori, Sergio
AU - Venditti, Adriano
PY - 2008/2
Y1 - 2008/2
N2 - Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34
+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34
+ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34
+ blast cells of 18 sAML and CD34
+ stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio
AB - Objectives: An aberrant pattern of expression of l-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34
+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). Methods: In a three-colour flow cytometric assay, we evaluated the expression of l-selectin and ICAM1 on CD34
+ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34
+ blast cells of 18 sAML and CD34
+ stem cells of 17 normal donors were also analysed. Results: The ratio of l-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of l-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio
KW - Adhesion molecules
KW - Flow-cytometry
KW - Intercellular adhesion molecule 1
KW - L-selectin
KW - Myelodysplastic syndromes
KW - Secondary acute myeloid leukaemia
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U2 - 10.1111/j.1600-0609.2007.00986.x
DO - 10.1111/j.1600-0609.2007.00986.x
M3 - Article
C2 - 18028430
AN - SCOPUS:38049096094
VL - 80
SP - 107
EP - 114
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 2
ER -