Evaluation of the prognostic value of impaired renal function on clinical progression in a large cohort of HIV-infected people seen for care in Italy

Alessandra Bandera, Andrea Gori, Francesca Sabbatini, Giordano Madeddu, Stefano Bonora, Raffaella Libertone, Claudio Mastroianni, Paolo Bonfanti, Antonella D Arminio Monforte, Alessandro Cozzi-Lepri, A. Giacometti, A. Costantini, S. Mazzoccato, G. Angarano, L. Monno, C. Santoro, F. Maggiolo, C. Suardi, P. Viale, M. BorderiE. Vanino, G. Verucchi, F. Castelli, E. Quiros Roldan, C. Minardi, T. Quirino, C. Abeli, Paolo Emilio Manconi, Paola Piano, J. Vecchiet, K. Falasca, L. Sighinolfi, D. Segala, F. Mazzotta, S. Lo Caputo, G. Cassola, C. Viscoli, A. Di Biagio, A. Alessandrini, R. Piscopo, G. Mazzarello, V. Belvisi, I. Caramma, A. Chiodera, P. Castelli, M. Moroni, M. Puoti, M. Galli, A. Lazzarin, G. Rizzardini, A. L. Ridolfo, R. Piolini, S. Rusconi, C. Balotta, A. Castagna, G. Marchetti, C. Tincati, P. Cicconi, M. C. Moioli, P. Cinque, N. Gianotti, S. Salpietro, L. Galli, L. Carenzi, R. Iardino, A. Tavelli, C. Mussini, G. Guaraldi, S. Marcotullio, C. Puzzolante, G. Lapadula, N. Abrescia, A. Chirianni, G. Borgia, A. Maddaloni, M. Gargiulo, I. Gentile, R. Orlando, F. Baldelli, D. Francisci, G. Parruti, T. Ursini, G. Magnani, Ma Ursitti, R. Cauda, A. Antinori, M. Andreoni, V. Vullo, F. Ceccherini-Silberstein, A. Cingolani, E. Girardi, A. D'Avino, I. Fanti, L. Gallo, G. Ippolito, C. Federico Perno, M. Lichtner, M. R. Capobianchi, E. Nicastri, R. Acinapura, A. Ammassari, M. Capozzi, G. Tebano, P. Lorenzini, F. Von Schloesser, M. Zaccarelli, F. Viviani, L. Sasset, M. S. Mura, A. De Luca, B. Rossetti, P. Caramello, G. Di Perri, G. Orofino, M. Sciandra, M. Bassetti, A. Londero, G. Pellizzer, V. Manfrin

Research output: Contribution to journalArticle

Abstract

Whilst renal dysfunction, especially mild impairment (60 die;ve (Icona) Foundation Study collected between January 2000 and February 2014 with at least two creatinine values available. eGFR (CKD-epi) and renal dysfunction defined using a priori cut-offs of 60 (severely impaired) and 90 ml/min/1.73m2 (mildly impaired). Characteristics of patients were described after stratification in these groups and compared using chi-square test (categorical variables) or Kruskal Wallis test comparing median values. Follow-up accrued from baseline up to the date of the CCVD or AIDS related events or death or last available visit. Kaplan Meier curves were used to estimate the cumulative probability of occurrence of the events over time. Adjusted analysis was performed using a proportional hazards Cox regression model. We included 7,385 patients, observed for a median follow-up of 43 months (interquartile range [IQR]: 21-93 months). Over this time, 130 cerebro-cardiovascular events (including 11 deaths due to CCVD) and 311 AIDS-related events (including 45 deaths) were observed. The rate of CCVD events among patients with eGFR >90, 60-89, 90, 60-89,

Original languageEnglish
Article numbere0124252
JournalPLoS One
Volume10
Issue number5
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Bandera, A., Gori, A., Sabbatini, F., Madeddu, G., Bonora, S., Libertone, R., Mastroianni, C., Bonfanti, P., Monforte, A. D. A., Cozzi-Lepri, A., Giacometti, A., Costantini, A., Mazzoccato, S., Angarano, G., Monno, L., Santoro, C., Maggiolo, F., Suardi, C., Viale, P., ... Manfrin, V. (2015). Evaluation of the prognostic value of impaired renal function on clinical progression in a large cohort of HIV-infected people seen for care in Italy. PLoS One, 10(5), [e0124252]. https://doi.org/10.1371/journal.pone.0124252