Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

G. Cennamo, R. S. Auriemma, D. Cardone, L. F S Grasso, N. Velotti, C. Simeoli, C. Di Somma, R. Pivonello, A. Colao, G. De Crecchio

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Abstract

PurposeThe aim of this prospective study was to measure the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and the ganglion cell complex (GCC) using spectral domain optical coherence tomography (SD-OCT) in a cohort of consecutive de novo patients with pituitary macroadenomas without chiasmal compression.Patients and methodsTwenty-two consecutive patients with pituitary macroadenoma without chiasmal compression (16 men, 6 women, aged 45.2±14.6 years, 43 eyes) entered the study between September 2011 and June 2013. Among them, 31.8% harboured a growth hormone-secreting pituitary adenoma, 27.3% a prolactin-secreting pituitary adenoma, 27.3% a corticotrophin-secreting pituitary adenoma, and 13.6% a non-secreting pituitary tumour. Eighteen subjects (nine females, nine males, mean age 36.47±6.37 years; 33 eyes) without pituitary adenoma, with normal ophthalmic examination, served as controls. In both patients and controls, cpRNFL and GCC thicknesses were measured by SD-OCT.ResultsPatients were significantly older (P=0.02) than controls. Best corrected visual acuity, intraocular pressure, colour fundus photography, and automatic perimetry test were within the normal range in patients and controls. Conversely, cpRNFL (P=0.009) and GCC (P

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalEye (London, England)
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 12 2015

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ASJC Scopus subject areas

  • Ophthalmology

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Cennamo, G., Auriemma, R. S., Cardone, D., Grasso, L. F. S., Velotti, N., Simeoli, C., Di Somma, C., Pivonello, R., Colao, A., & De Crecchio, G. (2015). Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression. Eye (London, England), 29(6), 797-802. https://doi.org/10.1038/eye.2015.35