Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture

O. Muratore, A. Pesce Schito, G. Cattarini, E. L. Tonoli, S. Gianoglio, S. Schiappacasse, L. Felli, F. Picchetta, G. C. Schito

Research output: Contribution to journalArticlepeer-review

Abstract

A simple assay capable of evaluating the trophic effect of growth factors or active principles on human skin diploid fibroblasts in primary culture has been developed. The results indicate that at physiological concentrations (20-100 μg/ml) a human placental polydeoxyribonucleotide (PDRN) preparation enhances the growth of human skin diploid fibroblasts of the knee in primary culture. This effect is consistently reproducible in the case of patients over 60 years of age, and may explain previously reported data on the successful clinical applications of human placental preparations, suggesting a selective benefit of PDRN in wound healing when compared to other treatments.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalCellular and Molecular Life Sciences
Volume53
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Human placental polydeoxyribonucleotide (PDRN)
  • Human skin fibroblasts
  • Primary tissue culture
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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