Valutazione dell'utilita dell'antigene NS5 nello screening pretrasfusionale per HCV

Translated title of the contribution: Evaluation of the use of NS5 antigens in pretransfusional screening for hepatitis C virus

A. Terrile, P. Strada, A. M. Solda, A. Correggi, G. Tripodi, G. Imberciadori

Research output: Contribution to journalArticlepeer-review

Abstract

Blood donations performed at Transfusion Service of Galliera Hospital in Genoa during 1995 (no. 8,937) and 1996 (no. 8,703) were screened for HCV antibodies using 3rd-generation diagnostic kits supplemented by Ortho- Clinical Diagnostics (solid phase coated with c22, c33, c100 and NS5 antigens). The prevalence of anti-HCV reactive donations was constantly of 0.6%. During these 2 years, the 0.2% of all donations was positive or indeterminate at supplementary test, using RIBA 3 (Ortho). The PCR test (supplemented by Roche) was positive either in 8/9 donors having a complete RIBA pattern and in 1 donor indeterminate at RIBA test with only anti-NS5. This result underlines the importance of the presence of NS5 antigen in the kit used in blood donation screening.

Translated title of the contributionEvaluation of the use of NS5 antigens in pretransfusional screening for hepatitis C virus
Original languageItalian
Pages (from-to)15-19
Number of pages5
JournalTrasfusione del Sangue
Volume43
Issue number1
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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