TY - JOUR
T1 - Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy
T2 - A case-control study
AU - Giambene, Barbara
AU - Sodi, Andrea
AU - Sofi, Francesco
AU - Marcucci, Rossella
AU - Fedi, Sandra
AU - Abbate, Rosanna
AU - Prisco, Domenico
AU - Menchini, Ugo
PY - 2009
Y1 - 2009
N2 - Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is a multifactorial disease that is caused by an infarction of the vessels that supply the optic nerve head. This study aims at evaluating the role of traditional and emerging cardiovascular risk factors on the development of NAION. Methods: A total of 85 newly diagnosed NAION patients and 107 age- and gender-matched healthy controls were studied. All participants underwent blood testing for homocysteine and lipoprotein(a). Plasma levels of vitamin B6 and B12, and folic acid were also determined. Plasma values of all these parameters were evaluated as continuous variables, by a logarithmic transformation. In addition, traditional cardiovascular risk factors were considered. Results: With univariate analysis, higher values of homocysteine and Lp(a) (OR 4.24, 95% CI 2.01-8.94, p<0.0001; OR 1.32, 95% CI 1.04-1.67, p=0.03, respectively) and lower values of vitamin B6 (OR 0.44, 95% CI 0.25-0.76, p=0.003) were significantly associated with NAION. At multivariate analysis, adjusted for age, gender, smoking habit, hypertension, dyslipidemia, diabetes, sleep apnea, and thrombophilic risk factors, the higher homocysteine and Lp(a) values (OR 5.74, 95% CI 2.41-13.67, p = 0.0001; OR 1.27, 95% CI 1.01-1.63, p=0.04) and lower vitamin B6 values (OR 0.42, 95% CI 0.23-0.77, p=0.005) maintained their significant relationship with NAION. Conclusions: This study demonstrated that elevated plasma homocysteine and lipoprotein(a) levels, as well as low vitamin B6 levels, may increase the risk of developing NAION. A screening for these thrombophilic markers could be useful in subjects experiencing NAION.
AB - Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is a multifactorial disease that is caused by an infarction of the vessels that supply the optic nerve head. This study aims at evaluating the role of traditional and emerging cardiovascular risk factors on the development of NAION. Methods: A total of 85 newly diagnosed NAION patients and 107 age- and gender-matched healthy controls were studied. All participants underwent blood testing for homocysteine and lipoprotein(a). Plasma levels of vitamin B6 and B12, and folic acid were also determined. Plasma values of all these parameters were evaluated as continuous variables, by a logarithmic transformation. In addition, traditional cardiovascular risk factors were considered. Results: With univariate analysis, higher values of homocysteine and Lp(a) (OR 4.24, 95% CI 2.01-8.94, p<0.0001; OR 1.32, 95% CI 1.04-1.67, p=0.03, respectively) and lower values of vitamin B6 (OR 0.44, 95% CI 0.25-0.76, p=0.003) were significantly associated with NAION. At multivariate analysis, adjusted for age, gender, smoking habit, hypertension, dyslipidemia, diabetes, sleep apnea, and thrombophilic risk factors, the higher homocysteine and Lp(a) values (OR 5.74, 95% CI 2.41-13.67, p = 0.0001; OR 1.27, 95% CI 1.01-1.63, p=0.04) and lower vitamin B6 values (OR 0.42, 95% CI 0.23-0.77, p=0.005) maintained their significant relationship with NAION. Conclusions: This study demonstrated that elevated plasma homocysteine and lipoprotein(a) levels, as well as low vitamin B6 levels, may increase the risk of developing NAION. A screening for these thrombophilic markers could be useful in subjects experiencing NAION.
KW - Homocysteine
KW - Lipoprotein(a)
KW - Non-arteritic anterior ischemic optic neuropathy
KW - Thrombophilia
KW - Vitamins
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U2 - 10.1007/s00417-008-0981-6
DO - 10.1007/s00417-008-0981-6
M3 - Article
C2 - 19052769
AN - SCOPUS:64449084638
VL - 247
SP - 693
EP - 697
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 5
ER -