Evaluation of two consecutive regimens in advanced gastric cancer

Franco Figoli, Enzo Galligioni, Diana Crivellari, Sergio Frustaci, Renato Talamini, Roberto Sorio, Silvana Saracchini, Salvatore Tumolo, Giovanni Lo Re, Silvio Monfardini

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Abstract

Treatment of gastric cancer still presents a challenge in cancer chemotherapy. In our Institute, from January 1981 to November 1984, 45 patients were given 5-fluorouracil (5FU) 600 mg/m2 Days 1, 8, 29, and 36; doxorubicin (A) 30 mg/m2 Days 1 and 29; mitomycin-C 10 mg/m2 Day 1 (FAM regimen) every 8 weeks. From December 1984 to October 1986, 26 patients were treated with 5FU 300 mg/m2 on Days 1-5, A 40 mg/m2 on Day 1, cisplatin (P) 100 mg/m2 on Day 1 (FAP regimen) every 3 weeks. In the FAM group, 42 patients are evaluable for response; 5 (12% partial remission (PR), 9 stable disease (SD), and 28 progressions (PRO) were observed. Median duration of response (MDR) was 21 weeks (range 13-45) and the median survival (MS) in the whole group was 27 weeks. In the FAP group, 23 patients are evaluable: 2 CR (9% 11 PR (47% 2 SD (9% and 8 PRO (34% were observed; CR duration was 24 and 107+ weeks, respectively, MDR of PR was 22 weeks (5-35). The MS of all patients was 16 weeks. Toxicity (WHO criteria) was mild in the FAM group and severe in the FAP group. In spite of a higher objective response rate, the short MS and the severe toxicity observed in the FAP group do not merit recommendation of this regimen in patients with gastric cancer; therefore neither FAM nor FAP appear to be an ideal standard therapy.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalCancer Investigation
Volume9
Issue number3
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Figoli, F., Galligioni, E., Crivellari, D., Frustaci, S., Talamini, R., Sorio, R., Saracchini, S., Tumolo, S., Re, G. L., & Monfardini, S. (1991). Evaluation of two consecutive regimens in advanced gastric cancer. Cancer Investigation, 9(3), 257-262. https://doi.org/10.3109/07357909109021322