Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects

G. Derosa, A. D'Angelo, C. Tinelli, E. Devangelio, A. Consoli, R. Miccoli, G. Penno, S. Del Prato, S. Paniga, A. F G Cicero

Research output: Contribution to journalArticlepeer-review


Objectives: We hypothesized that molecules active in vascular remodeling (i.e. MMPs and their TIMPs) could be modified in diabetic patients, as indirect markers of the diabetes related generalized abnormality of vascular activity. To test this hypothesis, we measured the plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in type 2 diabetic patients and in healthy subjects. Methods: We enrolled 181 diabetic patients and 165 controls. We measured body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct) fibrinogen (Fg), high sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Results: A significant increase (P <0.0001) of BMI, HbA1c, FPG, FPI, HOMA index, SBP, DBP, TC, LDL-C, Tg, Lp(a), PAI-1, Hct, Fg, and hs-CRP was present in the diabetic group, with a significant decrease (P <0.0001) of HDL-C levels compared to healthy subjects. MMP-2 and MMP-9 levels were significantly higher (P <0.0001) in diabetic patients. Significant TIMP-1, and TIMP-2 increase was also observed (P <0.0001) in the diabetic group. Conclusion: Plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 are increased in diabetic patients which may reflect abnormal extracellular matrix (ECM) metabolism.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalDiabetes and Metabolism
Issue number2
Publication statusPublished - Apr 2007


  • Diabetes
  • Extracellular matrix
  • Matrix metalloproteinases
  • Tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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