Eveningness and poor sleep quality contribute to depressive residual symptoms and behavioral inhibition in patients with bipolar disorder

Danila Caruso, Manon Meyrel, Karoline Krane-Gartiser, Victoire Benard, Chloé Benizri, Héléna Brochard, Pierre Alexis Geoffroy, Gregory Gross, Julia Maruani, Cecilia Prunas, Sunthavy Yeim, Laura Palagini, Liliana Dell’Osso, Marion Leboyer, Frank Bellivier, Bruno Etain

Research output: Contribution to journalArticle

Abstract

Eveningness and sleep disturbances are considered as markers of Bipolar Disorder (BD) and influence mood and emotional or behavioral states. This study investigates the associations between circadian markers and sleep quality on residual depressive symptoms and inhibition/activation dimensions during the euthymic phase. A sample of 89 euthymic adult individuals with BD was assessed for circadian preference and typology using the Composite Scale of Morningness (CSM) and the Circadian Type Inventory (CTI) and for sleep quality using the Pittsburgh Sleep Quality Index (PSQI). The Montgomery and Asberg Depression Rating Scale (MADRS) and the Multidimensional Assessment of Thymic States (MAThyS) were used to measure residual depressive symptoms and the inhibition/activation dimensions. We examined any associations between these parameters using correlations and path analyses. We identified significant associations between eveningness and poorer sleep quality that correlated to higher depressive residual symptoms and a global inhibition. The use of path analyses led us to conclude that poor sleep quality mediated the relationship between eveningness and either residual mood symptoms or behavioral inhibition (motivation, sensory perception, interpersonal interaction, and cognition). These factors should be considered in the clinical evaluation of individuals with BD, with a specific attention during the euthymic phase, in order to achieve the best functional outcome possible.

Original languageEnglish
JournalChronobiology International
DOIs
Publication statusAccepted/In press - Jan 1 2019
Externally publishedYes

Keywords

  • bipolar disorder
  • depressive symptoms
  • Eveningness
  • inhibition/activation
  • sleep quality

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Caruso, D., Meyrel, M., Krane-Gartiser, K., Benard, V., Benizri, C., Brochard, H., Geoffroy, P. A., Gross, G., Maruani, J., Prunas, C., Yeim, S., Palagini, L., Dell’Osso, L., Leboyer, M., Bellivier, F., & Etain, B. (Accepted/In press). Eveningness and poor sleep quality contribute to depressive residual symptoms and behavioral inhibition in patients with bipolar disorder. Chronobiology International. https://doi.org/10.1080/07420528.2019.1685533