Event-related potential study in young insulin-dependent diabetic patients

Massimiliano Oliveri, Giuseppe Caravaglios, Antonella Aloisio, Daniela Buffa, Vincenzo La Bua, Maria D'Alessandro, Brigida Fierro

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Event-related potential study in young insulin-dependent diabetic patients. Thirty young insulin-dependent diabetic patients with ten or more years duration of disease have been examined with acoustic Event Related Potentials (P300) and a battery of neuropsychological tests. The aim of the study was to analyze the frequency of cognitive impairment in IDDM and to compare neurophysiologicl with psychometric data. Mean P300 latency was significantly prolonged in diabetics compared to the controls (p <0.05). When analyzed individually, results showed that eight (27%) patients presented abnormal ERP values. Mean neuropsychological test scores were in the normal range. P300 latencies showed a nearly significant correlation (p = 0.07; r 2=0.11) with selective attention scores. No other correlations were found between P300 and neuropsychological test scores as well as between cognitive impairment and age, age at onset, duration of disease, HbA1c levels. The present study confirms the occurrence of cognitive dysfunctions in about 30% of IDDM patients and emphasizes the role of ERP recordings for an early diagnosis in asymptomatic patients.

Original languageEnglish
JournalNuova Rivista di Neurologia
Issue number6
Publication statusPublished - 1997


  • Cognitive impairment
  • Insulin-dependent diabetes mellitus
  • P300

ASJC Scopus subject areas

  • Clinical Neurology


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