Event-related potentials in idiopathic rapid eye movements sleep behaviour disorder

Alberto Raggi, Mauro Manconi, Monica Consonni, Cristina Martinelli, Marco Zucconi, Stefano F. Cappa, Luigi Ferini-Strambi

Research output: Contribution to journalArticle

Abstract

Objective: To assess psychophysiological parameters in idiopathic rapid eye movements sleep behaviour disorder (RBD), in order to identify possible markers for pre or sub-clinical cognitive abnormalities. Methods: Sixteen consecutive unmedicated patients with idiopathic RBD and 16 age- and sex-matched controls performed active and passive auditory oddball paradigms and an attentional test. Results: There were no significant between-group latency and amplitude differences. The two groups showed a difference in the inter-peak interval between N100 and P200 in the active condition. A significant correlation between attentional matrices scores and N100 amplitude at Fz and Cz to standard stimuli in the passive condition was found in controls but not in patients. Conclusions: In RBD there are minimal event-related potentials (ERPs) abnormalities involving the early stages of information processing. Significance: ERPs are not sensitive to pre or sub-clinical cognitive abnormalities in RBD. In alternative, these findings might support the existence of a truly idiopathic RBD syndrome.

Original languageEnglish
Pages (from-to)669-675
Number of pages7
JournalClinical Neurophysiology
Volume118
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Mismatch negativity
  • Oddball P300
  • Rapid eye movements sleep behaviour disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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