Abstract
Aims: This study, conducted in a 'field-practice' scenario, investigates the effectiveness and safety of everolimus in the second-line treatment of metastatic renal cell carcinoma (mRCC) patients. Patients & methods: mRCC patients, who started everolimus 10 mg/day after failure of first-line VEGF receptor-targeted tyrosine kinase inhibitor, were included in this study. Study end points were treatment response, progression-free survival and tolerability. Results: In total, 100 patients were assessed; the median duration of everolimus treatment was 7.1 months (95% CI: 5.7-8.5). A total of 19% of patients experienced a partial response and 62% of patients reached a stable disease. Median progression-free survival was 8 months (95% CI: 6.7-9.3). A total of 75% of patients experienced adverse events; no grade 4 adverse events were reported. Conclusion: These findings, obtained in a 'field-practice' scenario, support the use of everolimus for mRCC patients who failed one VEGF receptor-targeted tyrosine kinase inhibitor.
Original language | English |
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Pages (from-to) | 219-224 |
Number of pages | 6 |
Journal | Future Oncology |
Volume | 11 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 1 2015 |
Keywords
- everolimus
- mRCC
- observational studies
- second-line therapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Medicine(all)