Everolimus as second-line therapy for metastatic renal cell carcinoma: A 'real-life' study

Mimma Rizzo, Gaetano Facchini, Clementina Savastano, Giuseppe Di Lorenzo, Luigi De Lucia, Luigi Maiorino, Beniamino Casale, Giuseppe Grimaldi, Roberta Formato, Antonio Febbraro, Giacomo Cartenì

Research output: Contribution to journalArticle

Abstract

Aims: This study, conducted in a 'field-practice' scenario, investigates the effectiveness and safety of everolimus in the second-line treatment of metastatic renal cell carcinoma (mRCC) patients. Patients & methods: mRCC patients, who started everolimus 10 mg/day after failure of first-line VEGF receptor-targeted tyrosine kinase inhibitor, were included in this study. Study end points were treatment response, progression-free survival and tolerability. Results: In total, 100 patients were assessed; the median duration of everolimus treatment was 7.1 months (95% CI: 5.7-8.5). A total of 19% of patients experienced a partial response and 62% of patients reached a stable disease. Median progression-free survival was 8 months (95% CI: 6.7-9.3). A total of 75% of patients experienced adverse events; no grade 4 adverse events were reported. Conclusion: These findings, obtained in a 'field-practice' scenario, support the use of everolimus for mRCC patients who failed one VEGF receptor-targeted tyrosine kinase inhibitor.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalFuture Oncology
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • everolimus
  • mRCC
  • observational studies
  • second-line therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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    Rizzo, M., Facchini, G., Savastano, C., Lorenzo, G. D., Lucia, L. D., Maiorino, L., Casale, B., Grimaldi, G., Formato, R., Febbraro, A., & Cartenì, G. (2015). Everolimus as second-line therapy for metastatic renal cell carcinoma: A 'real-life' study. Future Oncology, 11(2), 219-224. https://doi.org/10.2217/fon.14.170