Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors

L. Furian, C. Silvestre, L. Vallese, N. Baldan, P. Donato, L. Bonfante, F. Cavallin, F. Marchini, P. Rigotti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Despite potential renal and cardiovascular advantages of proliferation signal inhibitors, their de novo use in kidney transplantation (KT) from elderly donors (ED) is poorly documented. We retrospectively analyzed two consecutive cohorts of KT from ED: low-dose extended-release tacrolimus (Tac) was used from 2010 to 2012 and cyclosporine (Csa) was used from 2008 to 2010. Methods. Associated maintenance drugs were everolimus (Eve) and steroids. Outcomes were compared between groups over a 12-month follow-up. Fifty-six patients were analyzed in the Tac-Eve group and 54 in the Csa-Eve group. Results. There were no significant differences at baseline with the exception of older donors age in the Tac-Eve cohort (74 vs 71 years, P = .002). There were no deaths, primary non functions, or graft losses. Eight (14%) Tac-Eve and 15 (28%) Csa-Eve patients had delayed graft function (P = .10). Renal function was fairly stable over time (median cGFR 36e49 mL/min and 51e55 mL/min in single kidney transplantation and dual kidney transplantation patients, respectively) with no significant differences between groups at month 12. Surgical complications were infrequent and observed mostly in dual kidney transplantation recipients. Thirty-nine (70%) and 30 (56%) patients remained under their initial Tac-Eve or Csa-Eve regimen, respectively. Conclusions. Induction with Thymoglobuline and maintenance with Eve and low-dose extended-release Tac and steroids is safe and effective in renal transplant from ED.

Original languageEnglish
Pages (from-to)3390-3395
Number of pages6
JournalTransplantation Proceedings
Volume46
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Tissue Donors
Tacrolimus
Kidney
Kidney Transplantation
Steroids
Maintenance
Delayed Graft Function
Transplants
Everolimus
Transplant Recipients
Calcineurin Inhibitors
Cyclosporine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. / Furian, L.; Silvestre, C.; Vallese, L.; Baldan, N.; Donato, P.; Bonfante, L.; Cavallin, F.; Marchini, F.; Rigotti, P.

In: Transplantation Proceedings, Vol. 46, No. 10, 2014, p. 3390-3395.

Research output: Contribution to journalArticle

Furian, L, Silvestre, C, Vallese, L, Baldan, N, Donato, P, Bonfante, L, Cavallin, F, Marchini, F & Rigotti, P 2014, 'Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors', Transplantation Proceedings, vol. 46, no. 10, pp. 3390-3395. https://doi.org/10.1016/j.transproceed.2014.08.044
Furian, L. ; Silvestre, C. ; Vallese, L. ; Baldan, N. ; Donato, P. ; Bonfante, L. ; Cavallin, F. ; Marchini, F. ; Rigotti, P. / Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. In: Transplantation Proceedings. 2014 ; Vol. 46, No. 10. pp. 3390-3395.
@article{56709db3d9644c0fb5f6a2d17a617166,
title = "Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors",
abstract = "Background. Despite potential renal and cardiovascular advantages of proliferation signal inhibitors, their de novo use in kidney transplantation (KT) from elderly donors (ED) is poorly documented. We retrospectively analyzed two consecutive cohorts of KT from ED: low-dose extended-release tacrolimus (Tac) was used from 2010 to 2012 and cyclosporine (Csa) was used from 2008 to 2010. Methods. Associated maintenance drugs were everolimus (Eve) and steroids. Outcomes were compared between groups over a 12-month follow-up. Fifty-six patients were analyzed in the Tac-Eve group and 54 in the Csa-Eve group. Results. There were no significant differences at baseline with the exception of older donors age in the Tac-Eve cohort (74 vs 71 years, P = .002). There were no deaths, primary non functions, or graft losses. Eight (14{\%}) Tac-Eve and 15 (28{\%}) Csa-Eve patients had delayed graft function (P = .10). Renal function was fairly stable over time (median cGFR 36e49 mL/min and 51e55 mL/min in single kidney transplantation and dual kidney transplantation patients, respectively) with no significant differences between groups at month 12. Surgical complications were infrequent and observed mostly in dual kidney transplantation recipients. Thirty-nine (70{\%}) and 30 (56{\%}) patients remained under their initial Tac-Eve or Csa-Eve regimen, respectively. Conclusions. Induction with Thymoglobuline and maintenance with Eve and low-dose extended-release Tac and steroids is safe and effective in renal transplant from ED.",
author = "L. Furian and C. Silvestre and L. Vallese and N. Baldan and P. Donato and L. Bonfante and F. Cavallin and F. Marchini and P. Rigotti",
year = "2014",
doi = "10.1016/j.transproceed.2014.08.044",
language = "English",
volume = "46",
pages = "3390--3395",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors

AU - Furian, L.

AU - Silvestre, C.

AU - Vallese, L.

AU - Baldan, N.

AU - Donato, P.

AU - Bonfante, L.

AU - Cavallin, F.

AU - Marchini, F.

AU - Rigotti, P.

PY - 2014

Y1 - 2014

N2 - Background. Despite potential renal and cardiovascular advantages of proliferation signal inhibitors, their de novo use in kidney transplantation (KT) from elderly donors (ED) is poorly documented. We retrospectively analyzed two consecutive cohorts of KT from ED: low-dose extended-release tacrolimus (Tac) was used from 2010 to 2012 and cyclosporine (Csa) was used from 2008 to 2010. Methods. Associated maintenance drugs were everolimus (Eve) and steroids. Outcomes were compared between groups over a 12-month follow-up. Fifty-six patients were analyzed in the Tac-Eve group and 54 in the Csa-Eve group. Results. There were no significant differences at baseline with the exception of older donors age in the Tac-Eve cohort (74 vs 71 years, P = .002). There were no deaths, primary non functions, or graft losses. Eight (14%) Tac-Eve and 15 (28%) Csa-Eve patients had delayed graft function (P = .10). Renal function was fairly stable over time (median cGFR 36e49 mL/min and 51e55 mL/min in single kidney transplantation and dual kidney transplantation patients, respectively) with no significant differences between groups at month 12. Surgical complications were infrequent and observed mostly in dual kidney transplantation recipients. Thirty-nine (70%) and 30 (56%) patients remained under their initial Tac-Eve or Csa-Eve regimen, respectively. Conclusions. Induction with Thymoglobuline and maintenance with Eve and low-dose extended-release Tac and steroids is safe and effective in renal transplant from ED.

AB - Background. Despite potential renal and cardiovascular advantages of proliferation signal inhibitors, their de novo use in kidney transplantation (KT) from elderly donors (ED) is poorly documented. We retrospectively analyzed two consecutive cohorts of KT from ED: low-dose extended-release tacrolimus (Tac) was used from 2010 to 2012 and cyclosporine (Csa) was used from 2008 to 2010. Methods. Associated maintenance drugs were everolimus (Eve) and steroids. Outcomes were compared between groups over a 12-month follow-up. Fifty-six patients were analyzed in the Tac-Eve group and 54 in the Csa-Eve group. Results. There were no significant differences at baseline with the exception of older donors age in the Tac-Eve cohort (74 vs 71 years, P = .002). There were no deaths, primary non functions, or graft losses. Eight (14%) Tac-Eve and 15 (28%) Csa-Eve patients had delayed graft function (P = .10). Renal function was fairly stable over time (median cGFR 36e49 mL/min and 51e55 mL/min in single kidney transplantation and dual kidney transplantation patients, respectively) with no significant differences between groups at month 12. Surgical complications were infrequent and observed mostly in dual kidney transplantation recipients. Thirty-nine (70%) and 30 (56%) patients remained under their initial Tac-Eve or Csa-Eve regimen, respectively. Conclusions. Induction with Thymoglobuline and maintenance with Eve and low-dose extended-release Tac and steroids is safe and effective in renal transplant from ED.

UR - http://www.scopus.com/inward/record.url?scp=84926366275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926366275&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2014.08.044

DO - 10.1016/j.transproceed.2014.08.044

M3 - Article

C2 - 25498057

AN - SCOPUS:84926366275

VL - 46

SP - 3390

EP - 3395

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 10

ER -