Everybody In! No Bouncers at Tumor Gates

Ilio Vitale, Lorenzo Galluzzi

Research output: Contribution to journalArticlepeer-review


Two recent genomic studies suggest that a large fraction of human tumors evolves in the presence of limited negative selection against somatic mutations. In this context, specific genetic defects enable the establishment of a hypermutant state that may constitute a target for immunotherapeutic interventions.

Original languageEnglish
Pages (from-to)85-87
JournalTrends in Genetics
Issue number2
Publication statusAccepted/In press - Feb 2018


  • DNA mismatch repair
  • DNA replication
  • Immune checkpoint blockers
  • Microsatellite instability
  • Regulated cell death

ASJC Scopus subject areas

  • Genetics


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