Everybody In! No Bouncers at Tumor Gates

Ilio Vitale, Lorenzo Galluzzi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Two recent genomic studies suggest that a large fraction of human tumors evolves in the presence of limited negative selection against somatic mutations. In this context, specific genetic defects enable the establishment of a hypermutant state that may constitute a target for immunotherapeutic interventions.

Original languageEnglish
Pages (from-to)85-87
JournalTrends in Genetics
Volume34
Issue number2
DOIs
Publication statusAccepted/In press - Feb 2018

Fingerprint

Mutation
Neoplasms

Keywords

  • DNA mismatch repair
  • DNA replication
  • Immune checkpoint blockers
  • Microsatellite instability
  • Regulated cell death

ASJC Scopus subject areas

  • Genetics

Cite this

Everybody In! No Bouncers at Tumor Gates. / Vitale, Ilio; Galluzzi, Lorenzo.

In: Trends in Genetics, Vol. 34, No. 2, 02.2018, p. 85-87.

Research output: Contribution to journalArticle

Vitale, Ilio ; Galluzzi, Lorenzo. / Everybody In! No Bouncers at Tumor Gates. In: Trends in Genetics. 2018 ; Vol. 34, No. 2. pp. 85-87.
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