Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review

Stefano Palomba, Angela Falbo, Fulvio Zullo, Francesco Orio

Research output: Contribution to journalArticlepeer-review

Abstract

Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.

Original languageEnglish
Pages (from-to)1-50
Number of pages50
JournalEndocrine Reviews
Volume30
Issue number1
DOIs
Publication statusPublished - Feb 2009

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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