Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review

Stefano Palomba, Angela Falbo, Fulvio Zullo, Francesco Orio

Research output: Contribution to journalArticle

Abstract

Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.

Original languageEnglish
Pages (from-to)1-50
Number of pages50
JournalEndocrine Reviews
Volume30
Issue number1
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Polycystic Ovary Syndrome
Metformin
Insulin
Cardiovascular Abnormalities
Hyperandrogenism
Type 2 Diabetes Mellitus
Infertility
Pregnancy
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Evidence-based and potential benefits of metformin in the polycystic ovary syndrome : A comprehensive review. / Palomba, Stefano; Falbo, Angela; Zullo, Fulvio; Orio, Francesco.

In: Endocrine Reviews, Vol. 30, No. 1, 02.2009, p. 1-50.

Research output: Contribution to journalArticle

Palomba, Stefano ; Falbo, Angela ; Zullo, Fulvio ; Orio, Francesco. / Evidence-based and potential benefits of metformin in the polycystic ovary syndrome : A comprehensive review. In: Endocrine Reviews. 2009 ; Vol. 30, No. 1. pp. 1-50.
@article{0cdf08a2c88041f395180b9421f3f5f4,
title = "Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review",
abstract = "Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.",
author = "Stefano Palomba and Angela Falbo and Fulvio Zullo and Francesco Orio",
year = "2009",
month = "2",
doi = "10.1210/er.2008-0030",
language = "English",
volume = "30",
pages = "1--50",
journal = "Endocrine Reviews",
issn = "0163-769X",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Evidence-based and potential benefits of metformin in the polycystic ovary syndrome

T2 - A comprehensive review

AU - Palomba, Stefano

AU - Falbo, Angela

AU - Zullo, Fulvio

AU - Orio, Francesco

PY - 2009/2

Y1 - 2009/2

N2 - Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.

AB - Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.

UR - http://www.scopus.com/inward/record.url?scp=60549105378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549105378&partnerID=8YFLogxK

U2 - 10.1210/er.2008-0030

DO - 10.1210/er.2008-0030

M3 - Article

C2 - 19056992

AN - SCOPUS:60549105378

VL - 30

SP - 1

EP - 50

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 1

ER -