TY - JOUR
T1 - Evidence-based guidelines for the management of exocrine pancreatic insufficiency after pancreatic surgery
AU - Sabater, Luis
AU - Ausania, Fabio
AU - Bakker, Olaf J.
AU - Boadas, Jaume
AU - Dominguez-Munoz, J. Enrique
AU - Falconi, Massimo
AU - Fernández-Cruz, L.
AU - Frulloni, Luca
AU - González-Sánchez, Victor
AU - Larino-Noia, José
AU - Lindkvist, Björn
AU - Luis, Félix
AU - Morera-Ocón, Francisco
AU - Martin-Pérez, Elena
AU - López, Marra
AU - Moya-Herraiz, Ángel
AU - Neoptolemos, John P.
AU - Pascual, Isabel
AU - Pérez-Aisa, Angeles
AU - Pezzilli, Raffaele
AU - Ramia, José M.
AU - Sánchez, Belinda
AU - De-Madaria, Enrique
PY - 2016/11/28
Y1 - 2016/11/28
N2 - Objective: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery. Background: EPI is a common complication after pancreatic surgery but there is certain confusion about its frequency, optimal methods of diagnosis, and when and how to treat these patients. Methods: Eighteen multidisciplinary reviewers performed a systematic review on 10 predefined questions following the GRADE methodology. Six external expert referees reviewed the retrieved information. Members from Spanish Association of Pancreatology were invited to suggest modifications and voted for the quantification of agreement. Results: These guidelines analyze the definition of EPI after pancreatic surgery, (one question), its frequency after specific techniques and underlying disease (four questions), its clinical consequences (one question), diagnosis (one question), when and how to treat postsurgical EPI (two questions) and its impact on the quality of life (one question). Eleven statements answering those 10 questions were provided: one (9.1%) was rated as a strong recommendation according to GRADE, three (27.3%) as moderate and seven (63.6%) as weak. All statements had strong agreement.
AB - Objective: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery. Background: EPI is a common complication after pancreatic surgery but there is certain confusion about its frequency, optimal methods of diagnosis, and when and how to treat these patients. Methods: Eighteen multidisciplinary reviewers performed a systematic review on 10 predefined questions following the GRADE methodology. Six external expert referees reviewed the retrieved information. Members from Spanish Association of Pancreatology were invited to suggest modifications and voted for the quantification of agreement. Results: These guidelines analyze the definition of EPI after pancreatic surgery, (one question), its frequency after specific techniques and underlying disease (four questions), its clinical consequences (one question), diagnosis (one question), when and how to treat postsurgical EPI (two questions) and its impact on the quality of life (one question). Eleven statements answering those 10 questions were provided: one (9.1%) was rated as a strong recommendation according to GRADE, three (27.3%) as moderate and seven (63.6%) as weak. All statements had strong agreement.
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U2 - 10.1097/SLA.0000000000001732
DO - 10.1097/SLA.0000000000001732
M3 - Review article
AN - SCOPUS:84995694122
VL - 264
SP - 949
EP - 958
JO - Annals of Surgery
JF - Annals of Surgery
SN - 0003-4932
IS - 6
ER -