Linee guida basate sull'evidenza per la prevenzione e terapia del tromboembolismo venoso

Translated title of the contribution: Evidence-based guidelines for the prevention and therapy of venous thromboembolism

Michela Falciani, Beatrice Dilaghi, Andrea Alberto Conti, Sabina Caciolli, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review


Recently, evidence-based guidelines for the prevention and therapy of venous thromboembolism have been published. Prophylaxis: in General Surgery patients with moderate to severe risk need to be treated with unfractioned (UFH) or low molecular weight (LMWH) heparin. Non pharmacological methods must be reserved to patients with high hemorrhagic risk and in association to heparin to patients with particularly high thromboembolic risk. In high risk Ortopedic Surgery prophylaxis with high doses LMWH or oral anticogulants (OA) is indicated. Il Neurosurgical Surgery and in politraumatized patients prophylaxis must be individualized taking account of hemorrhagic risk; patients with acute medullary lesion with paraplegia must be treated with LMWH. In Internal Medicine conditions which determine prolonged bed rest need prophylaxis with UFH or LMWH. In pregnancy, pharmacological prophylaxis is indicated only in cases of preceding thrombotic events or documented congenital risk factors. Therapy: deep venous thrombosis or sub-massive pulmonary embolism must be treated with anticoagulant doses of UFH or LMWH (100 U antiXa/Kg twice daily). OA must be continued for a time identifiable on the basis of underlying disease. In massive or sub-massive pulmonary embolism with hemodinamic instability thrombolysis is indicated. In heparin induced thrombocytopenia alternative antithrombotic treatments must be employed.

Translated title of the contributionEvidence-based guidelines for the prevention and therapy of venous thromboembolism
Original languageItalian
Pages (from-to)27-35
Number of pages9
JournalMinerva Cardioangiologica
Issue number12 SUPPL. 1
Publication statusPublished - Dec 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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