Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis - Establishing disease prognosis and monitoring patients

Mike P. Wattjes, Àlex Rovira, David Miller, Tarek A. Yousry, Maria P. Sormani, Nicola De Stefano, Mar Tintoré, Cristina Auger, Carmen Tur, Massimo Filippi, Maria A. Rocca, Franz Fazekas, Ludwig Kappos, Chris Polman, Frederik Barkhof, Xavier Montalban

Research output: Contribution to journalArticlepeer-review

Abstract

The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic process. MRI techniques can be used as regular monitoring to help stage patients with MS and measure disease progression. MRI can also be used to measure lesion burden, thus providing useful information for the prediction of long-term disability. With the introduction of a new generation of immunomodulatory and/or immunosuppressive drugs for the treatment of MS, MRI also makes an important contribution to the monitoring of treatment, and can be used to determine baseline tissue damage and detect subsequent repair. This use of MRI can help predict treatment response and assess the efficacy and safety of new therapies. In the second part of the MAGNIMS (Magnetic Resonance Imaging in MS) network's guidelines on the use of MRI in MS, we focus on the implementation of this technique in prognostic and monitoring tasks. We present recommendations on how and when to use MRI for disease monitoring, and discuss some promising MRI approaches that may be introduced into clinical practice in the near future.

Original languageEnglish
Pages (from-to)597-606
Number of pages10
JournalNature Reviews Neurology
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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