Abstract
(Table Presented) Migraine is a common and disabling disorder, affecting children, adolescents, and adults. Prophylactic therapy should be considered when specific clinical conditions are fulfilled. Its goal is to reduce the frequency and duration of the attacks as well as the severity of pain, thus allowing patients to regain routine activities and ameliorating their quality of life. Using the principles of evidence-based medicine, a review of available published data on the efficacy and safety of prophylactic treatments for migraine in children and adolescents is presented. Currently, only flunarizine and psychologically based interventions (e.g., relaxation training, biofeedback, and psychotherapeutic techniques) may be effective in migraine prophylaxis in children and adolescents. Owing to the paucity of evidence, there is a need for large, controlled, randomized, and masked trials. Clinical researchers should consider that migraine, especially in childhood and adolescence, is a complex condition, resulting from the interaction between biological, psychological, and environmental factors. Specific events, constitutional predisposition, individual and environmental-emotional dynamics can play a significant role in the genesis and evolution of pain. Age-related characteristics such as prevalence, diagnosis, quality of life, and therapy should be considered designing future studies.
| Original language | English |
|---|---|
| Pages (from-to) | 461-468 |
| Number of pages | 8 |
| Journal | Drug Development Research |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Dec 2007 |
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Keywords
- Adolescence
- Childhood
- Evidence-based
- Migraine
- Prophylactic treatment
- Review
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Evidence-based medicine in migraine prophylactic treatment in childhood and adolescence. / Balottin, Umberto; Ferri, Matteo; Termine, Cristiano.
In: Drug Development Research, Vol. 68, No. 7, 12.2007, p. 461-468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence-based medicine in migraine prophylactic treatment in childhood and adolescence
AU - Balottin, Umberto
AU - Ferri, Matteo
AU - Termine, Cristiano
PY - 2007/12
Y1 - 2007/12
N2 - (Table Presented) Migraine is a common and disabling disorder, affecting children, adolescents, and adults. Prophylactic therapy should be considered when specific clinical conditions are fulfilled. Its goal is to reduce the frequency and duration of the attacks as well as the severity of pain, thus allowing patients to regain routine activities and ameliorating their quality of life. Using the principles of evidence-based medicine, a review of available published data on the efficacy and safety of prophylactic treatments for migraine in children and adolescents is presented. Currently, only flunarizine and psychologically based interventions (e.g., relaxation training, biofeedback, and psychotherapeutic techniques) may be effective in migraine prophylaxis in children and adolescents. Owing to the paucity of evidence, there is a need for large, controlled, randomized, and masked trials. Clinical researchers should consider that migraine, especially in childhood and adolescence, is a complex condition, resulting from the interaction between biological, psychological, and environmental factors. Specific events, constitutional predisposition, individual and environmental-emotional dynamics can play a significant role in the genesis and evolution of pain. Age-related characteristics such as prevalence, diagnosis, quality of life, and therapy should be considered designing future studies.
AB - (Table Presented) Migraine is a common and disabling disorder, affecting children, adolescents, and adults. Prophylactic therapy should be considered when specific clinical conditions are fulfilled. Its goal is to reduce the frequency and duration of the attacks as well as the severity of pain, thus allowing patients to regain routine activities and ameliorating their quality of life. Using the principles of evidence-based medicine, a review of available published data on the efficacy and safety of prophylactic treatments for migraine in children and adolescents is presented. Currently, only flunarizine and psychologically based interventions (e.g., relaxation training, biofeedback, and psychotherapeutic techniques) may be effective in migraine prophylaxis in children and adolescents. Owing to the paucity of evidence, there is a need for large, controlled, randomized, and masked trials. Clinical researchers should consider that migraine, especially in childhood and adolescence, is a complex condition, resulting from the interaction between biological, psychological, and environmental factors. Specific events, constitutional predisposition, individual and environmental-emotional dynamics can play a significant role in the genesis and evolution of pain. Age-related characteristics such as prevalence, diagnosis, quality of life, and therapy should be considered designing future studies.
KW - Adolescence
KW - Childhood
KW - Evidence-based
KW - Migraine
KW - Prophylactic treatment
KW - Review
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UR - http://www.scopus.com/inward/citedby.url?scp=38849173837&partnerID=8YFLogxK
U2 - 10.1002/ddr.20215
DO - 10.1002/ddr.20215
M3 - Article
AN - SCOPUS:38849173837
VL - 68
SP - 461
EP - 468
JO - Drug Development Research
JF - Drug Development Research
SN - 0272-4391
IS - 7
ER -