Evidence-based PET for neurological diseases

Alberto Miceli, Selene Capitanio, Maria Isabella Donegani, Stefano Raffa, Anna Borra, Matteo Bauckneht, Silvia Morbelli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Over the past two decades, one of the major breakthroughs for the approach to neurological diseases both in the clinical and research settings has been represented by the validation of diagnostic biomarkers able to demonstrate the presence of pathological mechanisms, alteration in neurotransmission as well as to predict disease progression [1, 2]. The use of PET with different tracers as well as other imaging biomarkers support the etiological diagnosis of neurological disorders in vivo. This approach is particularly relevant in the field of neurodegenerative diseases. In fact, neurodegenerative diseases are characterized by the progressive degeneration and death of neurons. They represent a heterogeneous group of conditions characterized by different etiologies, different neuropathological and neurochemical alterations leading to different clinical pictures and courses [3]. Indeed, an early accurate diagnosis allows to tackle the disease with available or experimental intervention, lifestyle changes, or logistical arrangements, before disability has developed. Early intervention is expected to have greater clinical impact, extend independent and active life, improve its quality, and decrease the burden and costs of the disease [4]. However, the validation of PET tracers in neurological disease is still ongoing, and evidence on its comparative and combined diagnostic value with respect to other biomarkers is incomplete [4, 5]. As a matter of fact, the increasing pressure for cost-effectiveness requires systematic assessment and validation of all biomarker performance in the clinical settings. Similarly only an evidence-based approach to new PET tracers can allow to select the most promising tracers for PET imaging in the research field both for pathophysiological investigations and for upcoming diagnostic approaches.

Original languageEnglish
Title of host publicationEvidence-based Positron Emission Tomography
Subtitle of host publicationSummary of Recent Meta-analyses on PET
PublisherSpringer International Publishing
Pages125-136
Number of pages12
ISBN (Electronic)9783030477011
ISBN (Print)9783030477004
DOIs
Publication statusPublished - Jan 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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