Evidence for a different sensitivity to various central effects of interleukin-1 β in mice

Claudio Masotto, Giorgio Caspani, Maria Grazia De Simoni, Marina Mengozzi, Melania Scatturin, Marina Sironi, Angelo Carenzi, Pietro Ghezzi

Research output: Contribution to journalArticle

Abstract

Interleukin 1 (IL-1) induces a series of metabolic and endocrine effects. Activation of the hypothalamus-pituitary-adrenal axis, inhibition of food and water intake, elevation of serum interleukin-6 (IL-6) concentration and hypoglycemia are some of the effects induced by IL-1. The purpose of this study was to compare the sensitivity of these effects following central and peripheral administration of IL-1β. Different doses of IL-1β (0.1-1000 ng/mouse) were centrally (ICV) or peripherally (IP) injected to male mice two hours prior to sacrifice. The ICV administration was more efficacious than the IP injection in elevating serum corticosterone and IL-6 concentrations, whereas no difference was evident in the IL-1β-induced hypoglycemia. Central IL-1β administration was also more potent than IP injection in inhibiting overnight food and water intake. A dose-dependent effect was evident in all these cases. In summary, our data compare effects elicited by central or peripheral administration of different doses of IL-1β. This comparison suggests that the IL-1β stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1β-induced hypoglycemia.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalBrain Research Bulletin
Volume28
Issue number2
DOIs
Publication statusPublished - 1992

Keywords

  • Central nervous system
  • Corticosterone
  • Food intake
  • Glycemia
  • Interleukin
  • Intracerebroventricular
  • Intraperitoneal
  • Mice
  • Water intake

ASJC Scopus subject areas

  • Neuroscience(all)

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