Abstract
Hematopoietic progenitor (CD34+) cells were purified from the bone marrow of 6 human immunodeficiency virus (HIV) type 1-seropositive cytopenic patients and 10 healthy donors. HIV-1-seropositive patients showed a reduced number of granulocyte/macrophage, erythroid, and megakaryocyte progenitors and also a progressive and significant decline of numbers of CD34+ cells in liquid culture, which did not result from a productive or latent HIV-1 infection of CD34+cells. However, all HIV-1-seropositive patients showed signs of active viral replication at the bone marrow level. Moreover, virus isolates from 3 HIV-l-seropositive patients showed a dose-dependent inhibition on growth of normal CD34+cells. This suppressive activity was almost completely reversed by incubating the virus isolates with an anti-gp120 polyclonal antibody before adding to normal CD34+cells.
| Original language | English |
|---|---|
| Pages (from-to) | 710-716 |
| Number of pages | 7 |
| Journal | Journal of Infectious Diseases |
| Volume | 166 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression of Uninfected Hematopoietic (CD34+) Cells in AIDS Patients. / Zauli, Giorgio; Re, Maria Carla; Visani, Giuseppe; Furlini, Giuliano; Mazza, Patrizio; Vignoli, Monica; LaPlaca, Michele.
In: Journal of Infectious Diseases, Vol. 166, No. 4, 1992, p. 710-716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression of Uninfected Hematopoietic (CD34+) Cells in AIDS Patients
AU - Zauli, Giorgio
AU - Re, Maria Carla
AU - Visani, Giuseppe
AU - Furlini, Giuliano
AU - Mazza, Patrizio
AU - Vignoli, Monica
AU - LaPlaca, Michele
PY - 1992
Y1 - 1992
N2 - Hematopoietic progenitor (CD34+) cells were purified from the bone marrow of 6 human immunodeficiency virus (HIV) type 1-seropositive cytopenic patients and 10 healthy donors. HIV-1-seropositive patients showed a reduced number of granulocyte/macrophage, erythroid, and megakaryocyte progenitors and also a progressive and significant decline of numbers of CD34+ cells in liquid culture, which did not result from a productive or latent HIV-1 infection of CD34+cells. However, all HIV-1-seropositive patients showed signs of active viral replication at the bone marrow level. Moreover, virus isolates from 3 HIV-l-seropositive patients showed a dose-dependent inhibition on growth of normal CD34+cells. This suppressive activity was almost completely reversed by incubating the virus isolates with an anti-gp120 polyclonal antibody before adding to normal CD34+cells.
AB - Hematopoietic progenitor (CD34+) cells were purified from the bone marrow of 6 human immunodeficiency virus (HIV) type 1-seropositive cytopenic patients and 10 healthy donors. HIV-1-seropositive patients showed a reduced number of granulocyte/macrophage, erythroid, and megakaryocyte progenitors and also a progressive and significant decline of numbers of CD34+ cells in liquid culture, which did not result from a productive or latent HIV-1 infection of CD34+cells. However, all HIV-1-seropositive patients showed signs of active viral replication at the bone marrow level. Moreover, virus isolates from 3 HIV-l-seropositive patients showed a dose-dependent inhibition on growth of normal CD34+cells. This suppressive activity was almost completely reversed by incubating the virus isolates with an anti-gp120 polyclonal antibody before adding to normal CD34+cells.
UR - http://www.scopus.com/inward/record.url?scp=0026782492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026782492&partnerID=8YFLogxK
U2 - 10.1093/infdis/166.4.710
DO - 10.1093/infdis/166.4.710
M3 - Article
C2 - 1382106
AN - SCOPUS:0026782492
VL - 166
SP - 710
EP - 716
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -