Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression of Uninfected Hematopoietic (CD34+) Cells in AIDS Patients

Giorgio Zauli, Maria Carla Re, Giuseppe Visani, Giuliano Furlini, Patrizio Mazza, Monica Vignoli, Michele LaPlaca

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Hematopoietic progenitor (CD34+) cells were purified from the bone marrow of 6 human immunodeficiency virus (HIV) type 1-seropositive cytopenic patients and 10 healthy donors. HIV-1-seropositive patients showed a reduced number of granulocyte/macrophage, erythroid, and megakaryocyte progenitors and also a progressive and significant decline of numbers of CD34+ cells in liquid culture, which did not result from a productive or latent HIV-1 infection of CD34+cells. However, all HIV-1-seropositive patients showed signs of active viral replication at the bone marrow level. Moreover, virus isolates from 3 HIV-l-seropositive patients showed a dose-dependent inhibition on growth of normal CD34+cells. This suppressive activity was almost completely reversed by incubating the virus isolates with an anti-gp120 polyclonal antibody before adding to normal CD34+cells.

Original languageEnglish
Pages (from-to)710-716
Number of pages7
JournalJournal of Infectious Diseases
Volume166
Issue number4
DOIs
Publication statusPublished - 1992

Fingerprint

HIV-1
Acquired Immunodeficiency Syndrome
Bone Marrow
Viruses
Granulocyte-Macrophage Progenitor Cells
Megakaryocytes
Virus Diseases
Hematopoietic Stem Cells
Cell Count
Tissue Donors
HIV
Antibodies
Growth

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression of Uninfected Hematopoietic (CD34+) Cells in AIDS Patients. / Zauli, Giorgio; Re, Maria Carla; Visani, Giuseppe; Furlini, Giuliano; Mazza, Patrizio; Vignoli, Monica; LaPlaca, Michele.

In: Journal of Infectious Diseases, Vol. 166, No. 4, 1992, p. 710-716.

Research output: Contribution to journalArticle

Zauli, Giorgio ; Re, Maria Carla ; Visani, Giuseppe ; Furlini, Giuliano ; Mazza, Patrizio ; Vignoli, Monica ; LaPlaca, Michele. / Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression of Uninfected Hematopoietic (CD34+) Cells in AIDS Patients. In: Journal of Infectious Diseases. 1992 ; Vol. 166, No. 4. pp. 710-716.
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