Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

A. Ceriello, D. Giugliano, A. Quatraro, E. Marchi, M. Barbanti, P. Lefèbvre

Research output: Contribution to journalArticlepeer-review

Abstract

In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalDiabetologia
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1990

Keywords

  • Antithrombin III activity
  • fibrinopeptide A
  • hyperglycaemia
  • thrombin hyperactivity
  • thrombin-antithrombin III complex

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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