Abstract
In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.
| Original language | English |
|---|---|
| Pages (from-to) | 163-167 |
| Number of pages | 5 |
| Journal | Diabetologia |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1990 |
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Keywords
- Antithrombin III activity
- fibrinopeptide A
- hyperglycaemia
- thrombin hyperactivity
- thrombin-antithrombin III complex
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans. / Ceriello, A.; Giugliano, D.; Quatraro, A.; Marchi, E.; Barbanti, M.; Lefèbvre, P.
In: Diabetologia, Vol. 33, No. 3, 03.1990, p. 163-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans
AU - Ceriello, A.
AU - Giugliano, D.
AU - Quatraro, A.
AU - Marchi, E.
AU - Barbanti, M.
AU - Lefèbvre, P.
PY - 1990/3
Y1 - 1990/3
N2 - In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.
AB - In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.
KW - Antithrombin III activity
KW - fibrinopeptide A
KW - hyperglycaemia
KW - thrombin hyperactivity
KW - thrombin-antithrombin III complex
UR - http://www.scopus.com/inward/record.url?scp=0025238716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025238716&partnerID=8YFLogxK
U2 - 10.1007/BF00404044
DO - 10.1007/BF00404044
M3 - Article
C2 - 2184068
AN - SCOPUS:0025238716
VL - 33
SP - 163
EP - 167
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 3
ER -