Abstract
In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.
Original language | English |
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Pages (from-to) | 163-167 |
Number of pages | 5 |
Journal | Diabetologia |
Volume | 33 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1990 |
Keywords
- Antithrombin III activity
- fibrinopeptide A
- hyperglycaemia
- thrombin hyperactivity
- thrombin-antithrombin III complex
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism