Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

A. Ceriello; D. Giugliano; A. Quatraro; E. Marchi; M. Barbanti; P. Lefèbvre

doi:10.1007/BF00404044

Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

A. Ceriello, D. Giugliano, A. Quatraro, E. Marchi, M. Barbanti, P. Lefèbvre

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

Original language	English
Pages (from-to)	163-167
Number of pages	5
Journal	Diabetologia
Volume	33
Issue number	3
DOIs	https://doi.org/10.1007/BF00404044
Publication status	Published - Mar 1990

Keywords

Antithrombin III activity
fibrinopeptide A
hyperglycaemia
thrombin hyperactivity
thrombin-antithrombin III complex

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/BF00404044

Cite this

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title = "Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans",

abstract = "In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.",

keywords = "Antithrombin III activity, fibrinopeptide A, hyperglycaemia, thrombin hyperactivity, thrombin-antithrombin III complex",

author = "A. Ceriello and D. Giugliano and A. Quatraro and E. Marchi and M. Barbanti and P. Lef{\`e}bvre",

year = "1990",

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doi = "10.1007/BF00404044",

language = "English",

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pages = "163--167",

journal = "Diabetologia",

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T1 - Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

AU - Ceriello, A.

AU - Giugliano, D.

AU - Quatraro, A.

AU - Marchi, E.

AU - Barbanti, M.

AU - Lefèbvre, P.

PY - 1990/3

Y1 - 1990/3

N2 - In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

AB - In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

KW - Antithrombin III activity

KW - fibrinopeptide A

KW - hyperglycaemia

KW - thrombin hyperactivity

KW - thrombin-antithrombin III complex

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Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

Abstract

Keywords

ASJC Scopus subject areas

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