Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans

A. Ceriello, D. Giugliano, A. Quatraro, E. Marchi, M. Barbanti, P. Lefèbvre

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalDiabetologia
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1990

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Antithrombin III
Hyperglycemia
Fibrinopeptide A
Thrombin
Heparin
antithrombin III-protease complex
Diabetes Mellitus
Insulin

Keywords

  • Antithrombin III activity
  • fibrinopeptide A
  • hyperglycaemia
  • thrombin hyperactivity
  • thrombin-antithrombin III complex

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans. / Ceriello, A.; Giugliano, D.; Quatraro, A.; Marchi, E.; Barbanti, M.; Lefèbvre, P.

In: Diabetologia, Vol. 33, No. 3, 03.1990, p. 163-167.

Research output: Contribution to journalArticle

Ceriello, A, Giugliano, D, Quatraro, A, Marchi, E, Barbanti, M & Lefèbvre, P 1990, 'Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans', Diabetologia, vol. 33, no. 3, pp. 163-167. https://doi.org/10.1007/BF00404044
Ceriello, A. ; Giugliano, D. ; Quatraro, A. ; Marchi, E. ; Barbanti, M. ; Lefèbvre, P. / Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans. In: Diabetologia. 1990 ; Vol. 33, No. 3. pp. 163-167.
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