Evidence for a role of autoinflammation in early-phase psoriasis

D. Fanoni, L. Venegoni, B. Vergani, S. Tavecchio, A. Cattaneo, B. E. Leone, E. Berti, A. V. Marzano

Research output: Contribution to journalArticle

Abstract

Psoriasis is a common, inflammatory immune-mediated skin disease mainly presenting with plaques whose pathogenesis is based on the central role of the interleukin (IL)-23/IL-17 axis. However, the mechanisms acting in papular lesions of early-phase psoriasis are not fully understood. The aim of this study was to assess the involvement of autoinflammation, a state of sterile inflammation mainly driven by IL-1 over-production that has been recently hypothesized to act in the early phase of disease. Lesional skin of 10 patients with recent onset, untreated psoriasis has been investigated for expression of IL-1β, IL-17, IL-23 and other cytokines involved in the disease in comparison with normal skin of 10 healthy controls using a protein array method. Immunohistochemical phenotyping of inflammatory infiltrate and co-localization experiments with immunofluorescence confocal microscopy were conducted. IL-1β was significantly more expressed in psoriasis than in normal skin (P < 0·0001). The chemokine IL-8 was also over-expressed in psoriasis (P = 0·03) while IL-12, IL-17, IL-23, tumour necrosis factor-α and interferon-γ were only slightly more expressed in psoriasis than in normal skin, without reaching statistical significance. The inflammatory infiltrate consisted mainly of neutrophils with a relevant number of macrophages and dendritic cells and only scattered, predominantly T helper 1 lymphocytes. IL-1β co-localized mainly with CD66b, a neutrophil marker, suggesting that neutrophils were the major source of this cytokine. IL-1β over-expression in combination with low expression of cytokines that are predominant in late-phase plaque psoriasis may support the role of autoinflammation in early-phase disease, possibly paving the way to randomized trials with IL-1 antagonists.

Original languageEnglish
Pages (from-to)283-291
JournalClinical and Experimental Immunology
Volume198
Issue number3
DOIs
Publication statusPublished - 2019

Fingerprint

Psoriasis
Interleukin-1
Interleukin-23
Interleukin-17
Skin
Neutrophils
Cytokines
Protein Array Analysis
Interleukin-12
Helper-Inducer T-Lymphocytes
Interleukin-8
Fluorescence Microscopy
Chemokines
Skin Diseases
Confocal Microscopy
Dendritic Cells
Interferons
Tumor Necrosis Factor-alpha
Macrophages
Inflammation

Keywords

  • autoinflammatory disease
  • cytokines
  • neutrophils
  • skin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Fanoni, D., Venegoni, L., Vergani, B., Tavecchio, S., Cattaneo, A., Leone, B. E., ... Marzano, A. V. (2019). Evidence for a role of autoinflammation in early-phase psoriasis. Clinical and Experimental Immunology, 198(3), 283-291. https://doi.org/10.1111/cei.13370

Evidence for a role of autoinflammation in early-phase psoriasis. / Fanoni, D.; Venegoni, L.; Vergani, B.; Tavecchio, S.; Cattaneo, A.; Leone, B. E.; Berti, E.; Marzano, A. V.

In: Clinical and Experimental Immunology, Vol. 198, No. 3, 2019, p. 283-291.

Research output: Contribution to journalArticle

Fanoni, D, Venegoni, L, Vergani, B, Tavecchio, S, Cattaneo, A, Leone, BE, Berti, E & Marzano, AV 2019, 'Evidence for a role of autoinflammation in early-phase psoriasis', Clinical and Experimental Immunology, vol. 198, no. 3, pp. 283-291. https://doi.org/10.1111/cei.13370
Fanoni D, Venegoni L, Vergani B, Tavecchio S, Cattaneo A, Leone BE et al. Evidence for a role of autoinflammation in early-phase psoriasis. Clinical and Experimental Immunology. 2019;198(3):283-291. https://doi.org/10.1111/cei.13370
Fanoni, D. ; Venegoni, L. ; Vergani, B. ; Tavecchio, S. ; Cattaneo, A. ; Leone, B. E. ; Berti, E. ; Marzano, A. V. / Evidence for a role of autoinflammation in early-phase psoriasis. In: Clinical and Experimental Immunology. 2019 ; Vol. 198, No. 3. pp. 283-291.
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