Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas

Giorgio R. Merlo, Tiziana Venesio, Amelia Bernardi, Craig S. Cropp, Francesca Diella, Alberto P M Cappa, Robert Callahan, Daniel S. Liscia

Research output: Contribution to journalArticle

Abstract

The short area of chromosome 17 is a frequent target for deletions in human tumors, including breast cancer. We have investigated by restriction fragment polymorphism analysis the pattern of loss of heterozygosity (LOH) at four loci on 17p13.1-17pter in a panel of 110 primary human breast carcinomas. A copy of the p53 gene was lost in 23% of the informative cases. Point mutations in the p53 gene were statistically associated with LOH at the same locus (p = 0.003) but not at other loci on 17p13.3-17pter. A second region bordered by the loci D17S5/D17S28 (17p13.3) and D17S34 (17pter) is also affected by LOH, independent of point mutations in the p53 gene. We propose the presence of a second tumor suppressor gene within this region. In support of this hypothesis is the significant association (p = 0.005) between LOH at the D17S5/D17S28, but not at the TP53 or D17S34 loci, and tumors having a high S-phase index.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume76
Issue number2
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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