Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11

Peter Reed, Francesco Cucca, Suzanne Jenkins, Marilyn Merriman, Amanda Wilson, Patricia McKinney, Emanuele Bosi, Geir Joner, Kjersti Rønningen, Erik Thorsby, Dag Undlien, Tony Merriman, Anthony Barnett, Stephen Bain, John Todd

Research output: Contribution to journalArticlepeer-review

Abstract

A region of linkage to type 1 diabetes has been defined on human chromosome 10p11-q11 (IDDM10; P= 0.0007) using 236 UK and 76 US affected sibpairs and a 1 cM resolution microsatellite marker map. Analysis by the transmission disequilibrium test (TDT) in 1159 families with at least one diabetic child, from the UK, the US, Norway Sardinia and Italy provided additional support for linkage at D10S193 (P = 0.006, P(c) = 0.17). Notably, 5.1 cM distal to D10S193, marker D10S588 also provided positive TDT results (P = 0.009, P(c) = 0.25) but the allele under analysis was also preferentially transmitted to nonaffected siblings (P= 0.0008, P(c)= 0.02). This allele was positively associated in an independent UK case control study and, importantly, was neutrally transmitted in control CEPH families. These results suggest a type 1 diabetes susceptibility locus on chromosome 10p11-q11 (provisionally designated IDDM10) and demonstrate the necessity of analysis of non affected siblings in disease families, as well as analysis of control families.

Original languageEnglish
Pages (from-to)1011-1016
Number of pages6
JournalHuman Molecular Genetics
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 1997

ASJC Scopus subject areas

  • Genetics

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