Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection.

L. S. Fall, V. Chams, H. Le Coq, M. Fouchard, J. P. M'Bika, A. Gringeri, E. Santagostino, B. Bizzini

Research output: Contribution to journalArticle

Abstract

The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected patients, was most often stronger than that of sera from seronegative individuals. Furthermore, sera from HIV-infected patients actively immunized with i-IFN alpha invariably expressed INC in response to treatment, which was not the case for sera from control unimmunized patients. All sera from HIV-infected patients were found by ELISA to contain antibodies specifically directed to IFN alpha.

Original languageEnglish
Pages (from-to)409-416
Number of pages8
JournalCellular and Molecular Biology
Volume41
Issue number3
Publication statusPublished - May 1995

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology

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  • Cite this

    Fall, L. S., Chams, V., Le Coq, H., Fouchard, M., M'Bika, J. P., Gringeri, A., Santagostino, E., & Bizzini, B. (1995). Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection. Cellular and Molecular Biology, 41(3), 409-416.