Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas

Andrés J M Ferreri, Massimo Guidoboni, Maurilio Ponzoni, Carlo De Conciliis, Stefania Dell'Oro, Katharina Fleischhauer, Laura Caggiari, Antonia A. Lettini, Elena Dal Cin, Rosella Ieri, Massimo Freschi, Eugenio Villa, Mauro Boiocchi, Ricardo Dolcetti

Research output: Contribution to journalArticlepeer-review


Background: Ocular adnexal lymphomas may be antigen-driven disorders; however, the source of the putative antigen or antigens is still unknown. Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas. Methods: The presence of Chlamydia psittaci, trachomatis, and pneumoniae DNA was investigated by polymerase chain reaction in 40 ocular adnexal lymphoma samples, 20 nonneoplastic orbital biopsies, 26 reactive lymphadenopathy samples, and peripheral blood mononuclear cells (PBMCs) from 21 lymphoma patients and 38 healthy individuals. Seven patients with chlamydia-positive PBMCs were treated with the antibiotic doxycycline, and objective response was assessed in four patients with measurable lymphoma lesions. Differences in Chlamydiae DNA detection between the case patients and the control subjects were analyzed using the Fisher exact test. All statistical tests were two-sided. Results: Thirty-two of the 40 (80%) ocular adnexal lymphoma samples carried C. psittaci DNA, whereas all lymphoma samples were negative for C. trachomatis and C. pneumoniae. In contrast, none of the 20 nonneoplastic orbital biopsies (0% versus 80%; P

Original languageEnglish
Pages (from-to)586-594
Number of pages9
JournalJournal of the National Cancer Institute
Issue number8
Publication statusPublished - Apr 21 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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