Abstract
We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.
Original language | English |
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Pages (from-to) | 147-150 |
Number of pages | 4 |
Journal | Disease Markers |
Volume | 16 |
Issue number | 3-4 |
Publication status | Published - 2000 |
Keywords
- Polymorphic variant
- Prostate cancer
- Prostate cancer risk
- SRD5A2 gene
ASJC Scopus subject areas
- Medicine(all)
- Clinical Biochemistry