Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

K. Margiotti; F. Sangiuolo; A. De Luca; F. Froio; C. L. Pearce; V. Ricci-Barbini; F. Micali; M. Bonafe; C. Franceschi; B. Dallapiccola; G. Novelli; J. K V Reichardt

Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

K. Margiotti, F. Sangiuolo, A. De Luca, F. Froio, C. L. Pearce, V. Ricci-Barbini, F. Micali, M. Bonafe, C. Franceschi, B. Dallapiccola, G. Novelli, J. K V Reichardt

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)_n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

Original language	English
Pages (from-to)	147-150
Number of pages	4
Journal	Disease Markers
Volume	16
Issue number	3-4
Publication status	Published - 2000

Keywords

Polymorphic variant
Prostate cancer
Prostate cancer risk
SRD5A2 gene

ASJC Scopus subject areas

Medicine(all)
Clinical Biochemistry

Cite this

Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients. / Margiotti, K.; Sangiuolo, F.; De Luca, A.; Froio, F.; Pearce, C. L.; Ricci-Barbini, V.; Micali, F.; Bonafe, M.; Franceschi, C.; Dallapiccola, B.; Novelli, G.; Reichardt, J. K V.

In: Disease Markers, Vol. 16, No. 3-4, 2000, p. 147-150.

Research output: Contribution to journal › Article › peer-review

Margiotti, K. ; Sangiuolo, F. ; De Luca, A. ; Froio, F. ; Pearce, C. L. ; Ricci-Barbini, V. ; Micali, F. ; Bonafe, M. ; Franceschi, C. ; Dallapiccola, B. ; Novelli, G. ; Reichardt, J. K V. / Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients. In: Disease Markers. 2000 ; Vol. 16, No. 3-4. pp. 147-150.

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title = "Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients",

abstract = "We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.",

keywords = "Polymorphic variant, Prostate cancer, Prostate cancer risk, SRD5A2 gene",

author = "K. Margiotti and F. Sangiuolo and {De Luca}, A. and F. Froio and Pearce, {C. L.} and V. Ricci-Barbini and F. Micali and M. Bonafe and C. Franceschi and B. Dallapiccola and G. Novelli and Reichardt, {J. K V}",

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T1 - Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

AU - Margiotti, K.

AU - Sangiuolo, F.

AU - De Luca, A.

AU - Froio, F.

AU - Pearce, C. L.

AU - Ricci-Barbini, V.

AU - Micali, F.

AU - Bonafe, M.

AU - Franceschi, C.

AU - Dallapiccola, B.

AU - Novelli, G.

AU - Reichardt, J. K V

PY - 2000

Y1 - 2000

N2 - We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

AB - We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

KW - Polymorphic variant

KW - Prostate cancer

KW - Prostate cancer risk

KW - SRD5A2 gene

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Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

Abstract

Keywords

ASJC Scopus subject areas

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