Evidence for cd8+ cell increase in long-term puva-treated psoriatic patients after PUVA discontinuation

G. Borroni, C. Zaccone, G. Vignati, A. Fietta, C. Merlini, G. Rabbiosi

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term PUVA-treated psoriatic patients given maintenance therapy (UVA doses > 1.000 J/cm2) have been demonstrated to undergo lymphopenia and a decrease in the total number of circulating CD3+ andCD4+ T cells. The aim of this study was to assess whether the impairment of T cells is detectable also in psoriatic patients after long-lasting PUVA discontinuation. A group of 34 psoriatic patients (25 males. 9 females; mean age 52.7 ± 12.82 years), who had previously been treated by PUVA therapy (average cumulative dose 1,898.48± 1,207.12 J/cm2). was studied 1 year or more after discontinuation of PUVA therapy. The patients studied failed to show any impairment in CD3 + and CD4+ cells. Nevertheless, a significant increase (p

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalDermatology
Volume185
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • CD8+ T cell increase
  • Peripheral blood
  • Psoriasis
  • PUVA therapy discontinuation

ASJC Scopus subject areas

  • Dermatology

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