Evidence for defective T cell function in patients with alopecia areata

A. Giannetti, A. Di Silverio, A. M. Castellazzi, R. Maccario

Research output: Contribution to journalArticle

Abstract

The authors assess the percentage of peripheral blood lymphocytes forming rosettes with sheep erythrocytes (E-rosettes: T cells), as well as of lymphocytes forming rosettes with sheep erythrocytes coated with IgM antibody and complement (EAC rosettes: B cells) and of lymphocytes forming rosettes with human erythrocytes coated with anti-CD IgG antibodies (EA-rosettes: 'L' or 'null' cells) in 25 subjects affected by AA and in an equal number of age- and sex-matched healthy controls. The mean percentage of circulating T cells in subjects with AA (43.16±2.56 s.d.) was much lower than that of controls (61.3±0.53 s.d.). Of the 25 tested patients, only 7 had percentages of circulating T cells above 50 (the lower limit of normal range in our laboratory); 3 of the latter 7 patients were in remission, whereas all remaining patients had percentages of T lymphocytes below 50 and were in the active phase of the disease.

Original languageEnglish
Pages (from-to)361
Number of pages1
JournalBritish Journal of Dermatology
Volume98
Issue number3
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Dermatology

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    Giannetti, A., Di Silverio, A., Castellazzi, A. M., & Maccario, R. (1978). Evidence for defective T cell function in patients with alopecia areata. British Journal of Dermatology, 98(3), 361.