The authors assess the percentage of peripheral blood lymphocytes forming rosettes with sheep erythrocytes (E-rosettes: T cells), as well as of lymphocytes forming rosettes with sheep erythrocytes coated with IgM antibody and complement (EAC rosettes: B cells) and of lymphocytes forming rosettes with human erythrocytes coated with anti-CD IgG antibodies (EA-rosettes: 'L' or 'null' cells) in 25 subjects affected by AA and in an equal number of age- and sex-matched healthy controls. The mean percentage of circulating T cells in subjects with AA (43.16±2.56 s.d.) was much lower than that of controls (61.3±0.53 s.d.). Of the 25 tested patients, only 7 had percentages of circulating T cells above 50 (the lower limit of normal range in our laboratory); 3 of the latter 7 patients were in remission, whereas all remaining patients had percentages of T lymphocytes below 50 and were in the active phase of the disease.
|Number of pages||1|
|Journal||British Journal of Dermatology|
|Publication status||Published - 1978|
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