Evidence for differing dopaminergic activity in childhood- or adult-onset obesity

A. Catania, L. Cantalamessa, E. Venegoni, A. Orsatti, M. Baldini, C. Zanussi

Research output: Contribution to journalArticlepeer-review


In order to investigate dopaminergic activity in two types of human obesity, childhood- and adult-onset, we have studied the responses of plasma TSH and prolactin to domperidone, a dopamine receptor antagonist, in 12 patients obese since early childhood, 12 patients with adult-onset obesity, and in 12 lean controls. All subjects were females. In childhood-onset obese patients the responses of plasma prolactin and TSH to antidopaminergic stimulation were lower than those of adult-onset obese patients and lean controls. Conversely, the stimulus elicited a normal response of plasma prolactin and an exaggerated response of plasma TSH in adult-onset obese patients. These data indicate the presence of differing dopaminergic tone in the two types of human obesity.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalClinical Endocrinology
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Endocrinology


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