Evidence for Kaposi's sarcoma-associated herpes virus infection in patients with idiopathic pulmonary arterial hypertension: A case series and review of the literature

Naushad Hirani, Alessandra Manes, Carlo Parravicini, Chiara Scalamogna, Massimiliano Palazzini, Luca Negro, Serena Romanazzi, Erika Longhi, Giovanna Bestetti, Roberta Piolin, Giovanna Lunghi, Anna Orlandi, Angelo Branzi, Mario Corbellino, Nazzareno Galiè

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Abstract

Background. The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is unknown. Recent molecular and immunohistochemical evidence has demonstrated the presence of Kaposi's sarcoma-associated herpes virus (KSHV) at high frequency in lung tissue from patients with IPAH, suggesting a possible role for this virus in the pathogenesis of the disease. Materials and methods: Eighty-seven patients with IPAH (n = 45) or other forms of pulmonary hypertension (n = 42) were prospectively assessed for serologic evidence of KSHV, Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) infection. Immunofluorescence assays specific for antibodies against latency-associated and lytic antigens of KSHV, as well as commercially available kits that detect antibodies against HCMV and EBV nuclear antigens, were employed. Results: Only one patient with IPAH (2.2%) and one of the patients with other forms of pulmonary hypertension tested seropositive for KSHV. In contrast, 100% and more than 90% of patients with both forms of pulmonary hypertension were positive for EBV and HCMV antibodies, respectively. Conclusions: Italian patients with IPAH do not exhibit serologic evidence of KSHV infection despite a normal ability to mount antibody-mediated responses toward human herpes viruses. KSHV is unlikely to play a role in the pathogenesis of IPAH.

Original languageEnglish
JournalCurrent Medical Research and Opinion
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2007

Keywords

  • Idiopathic PAH
  • Kaposi sarcoma
  • Pulmonary arterial hypertension
  • Viruses

ASJC Scopus subject areas

  • Medicine(all)

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    Hirani, N., Manes, A., Parravicini, C., Scalamogna, C., Palazzini, M., Negro, L., Romanazzi, S., Longhi, E., Bestetti, G., Piolin, R., Lunghi, G., Orlandi, A., Branzi, A., Corbellino, M., & Galiè, N. (2007). Evidence for Kaposi's sarcoma-associated herpes virus infection in patients with idiopathic pulmonary arterial hypertension: A case series and review of the literature. Current Medical Research and Opinion, 23(SUPPL. 2). https://doi.org/10.1185/030079907X199583